1,2-Arylboration of aliphatic alkenes by cooperative palladium/copper catalysis

Cooperative Pd/Cu Catalysis for Alkene Arylboration: Opportunities for Divergent Reactivity

“…However, our lab has been able to develop arylboration reactions of strained alkenes such as norbornene and cyclobutene derivatives (Scheme G). While reactions of unactivated alkenes are particularly challenging, Semba et al have made a notable advance (Scheme H) . While not highlighted in this review, recent developments in Ni catalysis have led to the development of a general process for 1,2-arylboration of unactivated alkenes. , …”

“…While reactions of unactivated alkenes are particularly challenging, Semba et al have made a notable advance (Scheme 2H). 19 While not highlighted in this review, recent developments in Ni catalysis have led to the development of a general process for 1,2-arylboration of unactivated alkenes. 20,21 Among all the methods illustrated in Scheme 2, the control of selectivity has been achieved in some context, thus partly fulfilling the project goal outlined in Scheme 1.…”

Catalytic Arylboration of Spirocyclic Cyclobutenes: Rapid Access to Highly Substituted Spiro[3.n]alkanes

“…Along these lines, we became interested in derivatization of a spirocyclic cyclobutene by an alkene difunctionalization reaction. Our lab, , among others, − has advanced alkene arylboration reactions as a way to rapidly generate molecular complexity from simple alkene components. We envision that application of the principles learned to the challenge of spirocyclic cyclobutene functionalization would provide an enabling tool for the creation of rigid and complex saturated carbo- and heterocycles.…”