1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI): From an Obscure to Pivotal Member of the DOX Family of Serotonergic Psychedelic Agents – A Review
Richard A. Glennon,
Małgorzata Dukat
Abstract:1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane
(DOI, or DOX where
X = −I) was first synthesized in 1973 in a structure–activity
study to explore the effect of various aryl substituents on the then
newly identified, and subsequently controlled, hallucinogenic agent
1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM, or DOX where
X = −CH3). Over time, DOI was found to be a serotonin
(5-HT) receptor agonist using various peripheral 5-HT receptor tissue
assays and later, following the identification of multiple f… Show more
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