1,2,4-Triazolo[1,5-a]pyrimidines

Fischer, G.

doi:10.1016/s0065-2725(08)60887-9

Cited by 79 publications

(43 citation statements)

References 143 publications

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“…Different researchers have investigated them as chemotherapeutic agents, finding certain promising properties, such as growth inhibition of some microorganisms [5]. Studies Magá n/Marín/Rosales/Barrera/Salas/ Sá nchez-Moreno have also been performed on anti-tumor activity in cell lines, such as breast cancer MDA/MB-231, human colonrectal cancer COLO320 [6,7] and human colon cancer HT29 [8], where these complexes inhibit DNA synthesis.…”

Section: Introductionmentioning

confidence: 99%

Activities of Pt(II) and Ru(III) Triazole-Pyrimidine Complexes against Trypanosoma cruzi and T. brucei brucei

et al. 2004

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We studied the biological activity of three newly synthesized metal complexes of triazole-pyrimidine derivatives that were previously observed to inhibit in vitro growth of epimastigotes of Trypanosoma cruzi and procyclic forms of Trypanosoma bruceibrucei. We analyzed the possible inhibitory effect of these compounds on the synthesis of DNA, RNA and protein, ultrastructure and excretion of metabolites by these parasites. RNA synthesis was inhibited by all three complexes assayed. These complexes also led to anomalies of the main organelles (e.g. nucleus, kinetoplast and mitochondria). In addition, these complexes may be capable of altering the excretion of metabolites by the parasites.

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Section: Introductionmentioning

confidence: 99%

Activities of Pt(II) and Ru(III) Triazole-Pyrimidine Complexes against Trypanosoma cruzi and T. brucei brucei

et al. 2004

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“…The condensation of pyrimidine with triazole ring gives bicyclic heterocycles known as 1,2,4-triazolopyrimidines, which exist in four isomeric structure. [1][2][3][4] Among these four structural isomers, 1,2,4-triazolo [1,5-a]pyrimidine derivatives are thermodynamically more stable and most studied ones.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobal Activities of some Novel Triazolo[1,5-a]Pyrimidine Derivatives

Gami

Vilapara

Khunt

et al. 2014

ILCPA

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“…Four different possibilities exist for the relative orientation of both rings, so four different isomeric families of compounds are defined: 1,2,4-triazolo [1,5- Among these isomeric families of compounds, 1,2,4-triazolo[1,5-a]-pyrimidine derivatives are thermodynamically more stable and, thus, the most studied ones [15], a few of them being commercially available. Revisions surveying the synthesis, reactivity, spectroscopic characterization and crystallographic studies of 1,2,4-triazolo [1,5-c]-pyrimidines [16], 1,2,4-triazolo [4,3-a]pyrimidines [17] and 1,2,4-triazolo [4,3-c]pyrimidines [18] have also been published.…”

Section: Introductionmentioning

confidence: 99%