1,2,4-Triazoles

Synthesis of oleophilic electron-rich phenylhydrazines

“…Mono-arylhydrazines I are important intermediates in the synthesis of a number of heterocycles, including indoles [ 1 ] and some azoles (for example [ 2 – 3 ]), many of which exhibit biological activity and are used in drug development [ 4 – 6 ]. Arylhydrazines are also key intermediates in the preparation of stable radicals such as verdazyl [ 7 – 9 ] and benzo[1,2,4]triazinyls [ 10 – 12 ].…”

Regioselective synthesis of 1,2,4‐triazol‐3(2H)‐ones and their 3(2H)‐thiones: Kinetic studies and selective pyrolytic deprotection

“…Application of this procedure is now under investigation as a straightforward route to the 4-glycosyl derivatives of potential biological interest [6].…”

“…Electrophilic substitutions of asymmetric heterocyclic urea and thiourea derivatives (represented here by 1,2,4-triazol-3(2H)-ones and their 3-thione derivatives) are known to give mixtures of different regioisomeric products [1]. This usually leads to tedious separation and identifications.…”

New heteroatom-rich ring systems from N,N-dialkyl-N’-chlorosulfonyl chloroformamidines

“…Others have reported that 5-phenyl-3-mercapto[1,2,4]triazoles react with ambident electrophilic reagents such as -haloketones and 2-chloromethyloxirane firstly via the mercapto group and subsequently at N-2, rather than N-4, to afford bicyclic products. 56,57 This suggests an order of nucleophilicity for these mercaptotriazoles of S > N-2 > N-4. Our observations in the current work are consistent with the above and suggests the likelihood that the previously reported ..…”