1,2,4-Triazole-based benzothiazole/benzoxazole derivatives: Design, synthesis, p38α MAP kinase inhibition, anti-inflammatory activity and molecular docking studies

Design, Synthesis, and Antimicrobial Evaluation of New Annelated Pyrimido[2,1-c][1,2,4]triazolo[3,4-f][1,2,4]triazines

“…The presence of the nitro group in 18j was elucidated based on the IR spectrum, which showed two characteristic absorption bands at 1390 and 1520 cm −1 due to NO 2str (as and sym), respectively. The mass spectrum of 18j displayed an ion peak at m/z 530.09 (M + , 30%) corresponding to the expected molecular formula C 24 Upon smooth cyclocondensation of compound 10 with KSCN, ethyl cyanoacetate, acetic anhydride, benzoyl chloride, and thionyl chloride, a series of pyrimido- [1,2,4]triazolo- [1,2,4]triazine derivatives (19)(20)(21)(22)(23) were obtained (Scheme 5). The 1 H-NMR spectra of these compounds showed the lack of signals corresponding to the hydrazinyl protons originally observed in 10 ( 1 H-NMR) at 4.82 and 8.32 ppm.…”

“…Aza-heterocycles are amongst the medications which have diverse uses in the market (Figure 1). Of this class, 1,2,4-triazines [7][8][9][10][11][12][13] and 1,2,4-triazoles [14][15][16][17][18][19][20][21], as well as pyrimidines [22,23], have been introduced in a renewed generation of medication. Due to our interest in these azines, their ligation, and modification, we revisited and continued upon our previous research projects [24][25][26][27][28][29][30] with this study.…”

Therapeutic advancement of benzothiazole derivatives in the last decennial period

“…Tariq et al further synthesized novel N ‐(benzothiazol‐2‐yl)‐2‐[(5‐(phenoxymethyl)‐4‐aryl‐4 H ‐1,2,4‐triazol‐3‐yl)thio]acetamide derivatives and investigated them for their in vitro anti‐inflammatory activity and p38α MAP kinase inhibition. Compounds showing good in vitro activities were studied for their in vivo anti‐inflammatory activity using carrageenan‐induced rat paw edema model.…”

Discovery of 6‐Arylurea‐2‐arylbenzoxazole and 6‐Arylurea‐2‐arylbenzimidazole Derivatives as Angiogenesis Inhibitors: Design, Synthesis and in vitro Biological Evaluation

“…[27][28][29][30][31][32] Many of their derivatives are used for their anticancer, [33][34][35][36][37] antiviral, [38][39][40][41][42] antifungal, [43][44][45][46] antimicrobial, [47][48][49][50] anti-inflammatory, [51][52][53][54] analgesic, [55][56][57] andi mmunotropic [58][59][60] activities. [27][28][29][30][31][32] Many of their derivatives are used for their anticancer, [33][34][35][36][37] antiviral, [38][39][40][41][42] antifungal, …”

“…Benzoxazoles and benzimidazoles are ah ighly significant group of biological molecules that are widely found in agrochemicals, pharmaceuticals, synthetic drugs, and bioactive natural products. [27][28][29][30][31][32] Many of their derivatives are used for their anticancer, [33][34][35][36][37] antiviral, [38][39][40][41][42] antifungal, [43][44][45][46] antimicrobial, [47][48][49][50] anti-inflammatory, [51][52][53][54] analgesic, [55][56][57] andi mmunotropic [58][59][60] activities. Recently,6-substituted benzoxazole or benzimidazole derivatives have been developed as multi-kinasei nhibitors, including tyrosine and serine/threonine kinases.…”