1,2,4-Triazine Chemistry Part IV: Synthesis and Chemical Behavior of 3-Functionalized 5,6-Diphenyl-1,2,4-triazines towards Some Nucleophilic and Electrophilic Reagents

Abstract

The synthesis and chemical behavior of 3‐functionalized 5,6‐diphenyl‐1,2,4‐triazines towards some electrophilic and nucleophilic reagents are reviewed. The synthesis, unique features, and medicinal, pharmacological, and biological significance of these constituents are also reported.

Synthesis of New Heterocyclic Nitrogen System Bearing Thiazolopyrazole Moiety as New Biocidal Agents

“…On the other hand, pyrazoles showed a very important medicinal and pharmacological properties [4]. Various heterocyclic nitrogen systems such as phathalazine [5] and 1,2,4-triazine derivatives reported as antimicrobial, anti HIV, anticancer and molluscicidal agents against snail [6][7][8][9][10]. Upon these observations, the present work tends to combination of these heterocyclic in one novel systems in view of their antibacterial in the compare with antibiotics.…”

Synthesis of New Fluorinated 1,2,4-Triazino [3,4-b][1,3,4]thiadiazolones as Antiviral Probes-Part II-Reactivities of Fluorinated 3-Aminophenyl-1,2,4-triazinothiadiazolone

“…1,2,4-Triazine derivatives showed a wide biocidal spectrum [13]- [15]. Also, 1,3,4-thiadiazoles exhibited a large biocidal agents [11] [12].…”

“…Recently, synthesis and chemistry of 1,3,4-thiadiazoles as biocidal agents have been reviewed [11] [12]. Also, 1,2,4-triazine derivatives have been synthesized and evaluated as biological and pharmacological probes [13]- [15].…”

Synthetic Approach for Novel Fluorine Substituted <i>α</i>-Aminophosphonic Acids Containing 1,2,4-Triazin-5-One Moiety as Antioxidant Agents

“…Also, they use as anticancer [6], antibacterial [7], antiviral [8] and antioxidant [9] agents. On the other hands, functionally 1,2,4-triazines have unique properties for biological, medicinal and pharmacological chemistry [10] [11] [12]. Phosphorus compounds bearing and/or containing 1,2,4-triazine moieties exhibit a significant attention due to the specific biological properties [13] [14] [15] [16] [17].…”