1,2,4-Triazine Analogs as Novel Class of Therapeutic Agents

Abstract

1,2,4-Triazine nucleus is a prominent structural core system present in numerous pharmacologically active compounds. Till date, various 1,2,4-triazine analogs, possesing a wide range of potent pharmacological activities, have been reported. This review is an attempt to compile the medicinal chemistry aspects of various synthesized 1,2,4-triazine analogs reported so far.

Synthetic Approaches for Sulfur Derivatives Containing 1,2,4-Triazine Moiety: Their Activity for <i>in Vitro</i> Screening towards Two Human Cancer Cell Lines

“…2,3) Recognizing that a 1,2,4-triazine could be considered as an azapyrimidine, early work focused on the development of 6-azapyrimidine nucleotides and nucleosides. 4,5) This moiety has attracted much attention as a novel anticonvulsant for the treatment of epilepsy, [6][7][8] and in recent years, the 1,2,4-triazine ring system has been the object of much effort directed at identifying new anticancer drugs such as the hydrazide, or anti-human immunodeficiency virus (HIV) agents, exemplified by bromide.…”

6-Amino-3,4-dimethyl-1,2,4-triazin-1-ium 2-anilinobenzoate–3-amino-5,6-dimethyl-1,2,4-triazine (1/1)

“…Heterocyclic compounds play a role in the design of new drugs and materials (García-Valverde & Torroba, 2005;Kumar et al, 2014). 1,2,4-Triazines and their analogues occupy a important position in medicinal chemistry as a result of their pharmacological activities (Abdel-Monem, 2010).…”

Analogs of biologically active compounds IX. Synthesis of several new uracil and pteridine 6-aza-analogs based on cyclization of arylhydrazones derived from mesoxalic acid

“…Certain 1,2,4-triazines and pyrimido [1,2,4]triazines can be considered as analogues of naturally occurring Nheterocycles, especially of pyrimidine bases, purines and pteridines. Many 1,2,4-triazine derivatives are well known to possess biological activities.…”

“…Many 1,2,4-triazine derivatives are well known to possess biological activities. 2,3 Over the last two decades asymmetric triazines have been screened in vitro supporting their anticancer, [4][5][6] anti-HIV [4][5][6] and tuberculostatic activities. 7 Pyrimido [1,2,4]triazines show interesting biological activities, such as the antibiotics toxoflavine, reumycine, fervenuline and methylfervenuline all possessing a pyrimido [5,4-e][1,2,4]triazine (7-azapteridine) system.…”

“…

AbstractA series of 5C and 5N substituted 3-oxo-2-phenyl-1,2,4-triazine-6-carbonitriles and 8-imino-2-arylpyrimido [4,5-e] [1,2,4]triazine-3,6(2H,5H)-diones (6-aryl-6-azapteridines) are described via a cyclocondensation reaction from the corresponding aryliminohydrazones with CDI. The required aryliminohydrazones were obtained from the starting compound -malononitrile.

…”