1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

“…Moreover, 1,2,3-triazole could form diverse non-covalent interactions, such as hydrogen bonds, van der Waals forces, and dipole-dipole bonds with various enzymes, proteins, and receptors (Bonandi et al, 2017;Bozorov et al, 2019). Hence, 1,2,3-triazole derivatives exhibit a variety of promising biological properties, including antibacterial (Zhang, 2019;Xu, 2020), antimalarial (Chu et al, 2019;Feng et al, 2020), antitubercular (Zhang et al, 2017;Yan et al, 2020), antiviral (Rani et al, 2020;Feng et al, 2021), and anticancer (Lal and Yadav, 2018;Slavova et al, 2020) activities. For example, 1,2,3-triazoles could exert the anticancer potential by inducing the cell cycle arrest and apoptosis of cancer cells.…”

Design and Synthesis of New 5-aryl-4-Arylethynyl-1H-1,2,3-triazoles with Valuable Photophysical and Biological Properties

“…The biological properties of triazole derivatives are very diverse. Currently, among the most widely studied types of activity are: antibacterial [ 14 , 15 ], antiviral [ 16 ], and anticancer [ 17 , 18 ].…”

[Et3NH][HSO4] catalyzed solvent‐free synthesis of new 1,2,3‐triazolidene‐indolinone derivatives

“…[5] The 1,2,3-triazoles have attracted much more interest due to their extensive biological and pharmaceutical properties, including anticancer, [6] antitubercular, [7] antiinflammatory, [8] antioxidant, [9] antifungal, [10] and antibacterial. [11] The 1,2,3-triazole nucleus is featured in marketed drugs (Figure 1). The Mubritinib 1 has shown its effectiveness as anticancer medicament [12] for curing breast, bladder, kidney, and prostate cancer.…”