1.185 Mild cognitive impairment in Parkinson's disease

Cognitive Impairment in Parkinson Disease

“…The pattern we observed for progressively increasing levels of global disability or dependency (as per the Schwab and England scale but not the UPDRS-ADL scale) with worsening of cognitive impairment across the 3 groups supports our initial hypothesis and is consistent with the previous findings of a linear association between factors such as overall disease severity of PD and level of cognitive impairment. 29 Our own group has recently shown that in PD without dementia, 56% of the variance in disability could be accounted for by higher levels of apathy and depression, longer duration of disease, and more impaired motor function. 6 As PD progresses from the stage with intact cognition to PD-MCI and finally PDD, apathy and motor impairment also progress and disease duration lengthens, and these factors are all likely contributing to gradually increasing levels of disability, which is a multifactorial concept.…”