1,10-Phenanthroline Modulated Redox Potentials Explored for Benign Iron Speciation Analysis

Rizvi, Masood Ahmad; Teshima, Norio; Peerzada, Ghulam Mustafa

doi:10.5562/cca2167

Cited by 16 publications

(15 citation statements)

References 16 publications

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“…The amounts of total Fe 3þ and Fe 2þ were determined by potentiometric titration using a potentiometric titrator Metrohm 877 Titrino Plus as described by [21] and another authors [22,23]. As by Mossbauer spectroscopy it is not possible to determine the total content of iron but just the % of iron (II) and iron (III) with respect to the total iron present.…”

Section: Characterization Techniques and Methodsmentioning

confidence: 99%

Particles that slide over the water surface: Synthesis and characterization of iron oxides particles coated with PDMS, with hydrophobic and magnetic properties

Neto

Araújo

Guilherme

et al. 2015

Materials Chemistry and Physics

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Section: Characterization Techniques and Methodsmentioning

confidence: 99%

Particles that slide over the water surface: Synthesis and characterization of iron oxides particles coated with PDMS, with hydrophobic and magnetic properties

Neto

Araújo

Guilherme

et al. 2015

Materials Chemistry and Physics

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“…The Phen ligand forms complexes of different stabilities with two oxidation states (2+ and 3+) of iron [8,14]. Theoretical analysis of iron Phen complexes reveals a charge transfer absorption band involving π electron migration from the d-π (t 2 g type) orbitals of iron (HOMO) to the lowest vacant π* molecular orbital of the Phen ligand (LUMO).This electron migration between metal HOMO and ligand LUMO is considered to be of stabilizing nature as is evident from the higher formation constant of Fe(II)Phen complex (log β III = 21.3) over Fe(III)Phen complex (log β III = 14.1) [8].…”

mentioning

confidence: 99%

“…The complexation effect on redox potential can be explained by specific stabilization of transition metal oxidation states in a redox couple. The complexation effect on redox potential can be rationalized using the thermochemical cycle (Scheme 1) [7,8]. The ligand effect is the promising phenomenon in the design and development of redox potentials with desired applications [6].…”

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confidence: 99%

Complexation modulated redox behavior of transition metal systems (review)

Rizvi

2015

Russ J Gen Chem

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Ligand effect is a favorable factor in modulation of redox potential of transition metal ion oxidation-reduction systems. Coordination promoted redox action of transition metals can be an efficient approach to design of new redox systems with specific applications. The current review is devoted to the complexation effect of selected ligands on the redox potential of iron, cobalt and copper redox couples and application of such systems in analytical estimations. Indirect estimation of non redox systems by a non redox reaction over a platinum electrode has been referred to as a pseudo indicator action. Application of coordination modulated redox potentials in the natural attenuation of toxic environmental contaminants is also presented.1 The text was submitted by the author in English.Complexation effect on redox potential. Redox systems with tailor made potentials are desired for applications in artificial photosynthetic reactions [1], fuel cell catalysts solar energy conversions [2], hydrogen production and bio-memitic chemistry [3]. Complexation with an appropriate ligand can modulate the redox potential of transition metals redox couples beyond the natural range [4,5]. The complexation effect on redox potential can be explained by specific stabilization of transition metal oxidation states in a redox couple. The complexation effect on redox potential can be rationalized using the thermochemical cycle (Scheme 1) [7,8]. The ligand effect is the promising phenomenon in the design and development of redox potentials with desired applications [6].According to Eq. (3) the ratio of formation constants β III /β II modulates the redox potential of a redox couple in complexes. With the proper adjustment of the ratio the redox potential can be tuned to any desired value. Thus the electrochemical behavior of transition metals ions is also modified by the complexation effect which leads to a different reduction potential in the complexed state compared to the free state [Eq. (3)]. The complexation effect on redox potentials helps to understand mechanisms of the natural redox processes [9],Scheme 1. Thermochemical cycle for complexation effect on redox potential. M 3+ aqua M 2+ aqua ΔG 1 e − ΔG 3 nL ΔG 2 nL M 3+ complex M 2+ complex ΔG 4 e − (3) E complex = E aqua − RT nF ln β III β II . ΔG 1 + ΔG 2 = ΔG 3 + ΔG 4 , ΔG 1 = −nFE aqua ; ΔG 2 = −RTln β II , ΔG 3 = −RTln β III ; ΔG 4 = −nFE complex , ΔG 4 = (ΔG 1 + ΔG 2 ) − ΔG 3 , −nFE complex = −nFE aqua + RT nF ln β III β II ,

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“…[4] Recently metabolic enzyme expression has been linked to metabolic alterations which are being regarded as a hallmark of cancer. [5] In continuation of our work on anti cancer compounds [6][7][8][9][10] a schiff base of benzil and 4-aminoantipyrine -the two privileged molecules of drug development was designed. The motivation for selecting benzil amongst a plethora of aromatic 1,2 diketones is its prominent resemblance to anticancer natural product Combretastatin ( Figure 1) which has served as a fundamental scaffold for the synthesis of large number of compounds with antitumor activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Crystal Structure and in vitro DNA Binding Studies of Combretastatin A-4 Analogue

Rizvi¹,

Dangat²,

Yaseen³

et al. 2015

Croat. Chem. Acta

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Synthesis of a novel Combretastatin A-4 analogue using Schiff's reaction of benzil and 4-aminoantipyrine has been achieved under solvent free conditions. The structure of compound was examined spectroscopically and confirmed from single crystal diffraction studies. The synthesized Combretastatin A-4 analogue was investigated for its DNA binding ability as the plausible mechanism for its antitumor activity. The binding propensity of the synthesized compound with calf-thymus (CT) DNA was monitored with absorption and emission spectrophotometric titrations. The calculations predict a binding constant of 7.24 × 10 4 for the complex of the synthesized compound with CT DNA which is comparable in magnitude to that of DNA binding of bactericidal drug enoxacin and typical intercalation indicator ethidium bromide (EB). Competitive binding studies of the synthesized compound with EB using fluorescence titration reveal that it displaces the DNA-bound EB and binds in intercalative mode which was further supported by circular dichroism (CD) spectroscopy. The probable site and binding energy of the compound with DNA was further theoretically investigated by molecular docking studies. The significant DNA binding ability of the synthesized Combretastatin A4 analogue as revealed from this study could be related to the anticancer activity of the Combretastatin A4.

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1,10-Phenanthroline Modulated Redox Potentials Explored for Benign Iron Speciation Analysis

Cited by 16 publications

References 16 publications

Particles that slide over the water surface: Synthesis and characterization of iron oxides particles coated with PDMS, with hydrophobic and magnetic properties

Particles that slide over the water surface: Synthesis and characterization of iron oxides particles coated with PDMS, with hydrophobic and magnetic properties

Complexation modulated redox behavior of transition metal systems (review)

Synthesis, Crystal Structure and in vitro DNA Binding Studies of Combretastatin A-4 Analogue

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