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Vision and visual potential for perifoveal retinoblastoma after optical coherence tomographic-guided sequential laser photocoagulation

“…IIRC13 eye classification were groups B (10), C (7) and D (5). By the eighth edition of TNM,14 11 eyes were cT1b, 8 were cT2a and 3 were cT2b. The foveola was involved in all included eyes at presentation; five eyes had only the central tumour, while 17 eyes had additional peripheral tumours.…”

“…Retinoblastoma (IIRC13 groups B/C/D or T1b/T2a/T2b, eighth edition TNMH classification)14 size reduction by chemotherapy (systemic or IAC) is commonly followed by laser consolidation to achieve stable tumour control 1 16 17. The use of OCT to accurately locate the fovea and provide topographic macular assessment enabled refined focal therapy consolidation after chemotherapy 2…”

Reduction of severe visual loss and complications following intra-arterial chemotherapy (IAC) for refractory retinoblastoma

“…IAC was considered in cases where the tumours failed to respond adequately to previous treatments or there was a new recurrence not amenable to local therapy (laser, cryotherapy or plaque therapy). All patients were assessed b y one of the authors (MAR or MSS)  and graded according to the International Intraocular Retinoblastoma Classification (IIRC)7 an d American Joint Committee on Cancer Staging (AJCC) 8. All patients had received systemic chemotherapy in the form of six cycles of carboplatin, vincristine and etoposide as first-line treatment.…”

Posterior Vitreous Detachment and the Associated Risk of Retinal Toxicity with Intravitreal Melphalan Treatment for Retinoblastoma

“…Fifty-four eyes of 112 eyes (48%) were from female patients. The included eyes were classified by the IIRC [1] and TNM [23] with the largest proportion being Group D/cT2b eyes (50 of 112 eyes, 45%). The median follow-up time for all eyes from diagnosis was 31.5 months (interquartile range 28.3 months).…”

“…We classified eyes according to the International Intraocular Retinoblastoma Classification (IIRC) described by Linn Murphree [1] and the AJCC 8th edition TNM classification [23]. A retrospective chart review was done to obtain the following information: age at diagnosis, gender, laterality of retinoblastoma, length of follow-up, systemic chemotherapy agents used with the number of cycles, dates of first and last cycle of chemotherapy, time to recurrence, time to enucleation, number and dates of IVM injections with exact doses, and visual acuity of the treated eyes at last visit.…”