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Abstract

ABSTRACT:The effects of zingerone, on antidiabetic and hypolipidemic potential in streptozotocin-induced diabetic rats were investigated in the present study. Diabetes mellitus was induced by a single intraperitoneal administration of streptozotocin (40 mg/kg bwt). Five days after STZ administration, diabetic rats received zingerone (10 mg/kg bwt) orally for 30 days. Metformin (Met) was used as reference drug. Zingerone treatment significantly reduced blood glucose level, Lipid profiles of serum, liver and kidney showed higher reduction in the levels of phospholipids, triglycerides and free fatty acids of zingerone treated diabetic rats than STZ-induced diabetic rats and Met-treated diabetic rats. In addition, zingerone treatment of STZ-rats was found to be effective in preserving the normal histological appearance of pancreatic islets, liver, and kidney, whereas the untreated diabetic rats exhibited pathological features. Thus, zingerone may have the potential in managing the effects of diabetic complications in human subjects.