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Abstract

Objectives: In the treatment of acute myocardial infarction (MI), the time delay to achieve reperfusion of the infarction-related artery has been linked to survival rates. Primary or direct angioplasty has been found to be an excellent means of achieving reperfusion in acute ST-elevation MI compared to thrombolytic therapy in randomized trials. However, no mortality benefit of primary angioplasty over thrombolysis was observed in several registries, in which delays in performing primary angioplasty were longer. Our objectives were to evaluate the door-to-balloon time (DBT) in our institution and investigate its relationship with clinical and prognostic variables.

New Hydrogels Based on Agarose/Phytagel and Peptides

“…These were fixed in 10% formalin solution, thereafter, were embedded in paraffin and the 0.4 µm sections were made (on a microtome). The obtained samples were stained using the Masson's trichrome method and were histopathological evaluated [ 41 ] using a Nikon E600 Eclipse optical microscope equipped with a digital acquisition system for taking images of the examined preparations.…”

Microcirculation in Acute and Chronic Kidney Diseases

“…They may also contribute to impaired microcirculation and upregulate the release of proinflammatory cytokines within the capillaries, creating a positive feedback cycle in the inflammatory response. 44 Even if these interactions between leukocytes and endothelial cells are not kidney specific, there is increasing evidence that endothelial cell phenotypes vary between organs, with remarkable heterogeneity in structure and function. 45,46 For example, in a study of mouse endotoxemia, there was 18-fold induction of ICAM-1 messenger RNA expression in the kidney compared with 6-fold in the heart and 2-fold in the liver and lung.…”

ICS Medal Winners and Research Abstract Presentations

“…For example, during endotoxaemia and faecal peritonitis, there was a disproportionate early fall in liver tPO 2 . This could be due to changes in intrahepatic flow redistribution, 20 microcirculatory heterogeneity [21][22][23][24] and/or elevated hepatic metabolic activity as part of the acute phase response. 25 By contrast, tPO 2 decreased uniformly during hypoxaemia whereas renal cortical tPO 2 was maintained during haemorrhage despite significant reduction in macrovascular blood flow.…”

“…Sixteen patients were recruited (nine males, age 67 [55-72], APACHE II 23 [17][18][19][20][21][22][23][24][25][26][27][28][29][30]) of whom ten (63%) subsequently died. Significant changes were identified in global haemodynamics, red cell flux and tissue oxygenation.…”