Abstract:Recent estimate revealed that in the year 2012, about 227,000 American women suffered from metastatic breast cancer (mBC). The U.S. Food and Drug Administration (FDA) have approved ado-trastuzumab emtansine (T-DM1) on 22 February 2013 for the treatment of human epidermal growth factor receptor (HER2)-positive mBC who has previously been treated with trastuzumab and a taxane. T-DM1 received the European Commission approval on November 2013 based on results from the pivotal Phase III EMILIA trial and Switzerland… Show more
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