09C: Desarrollo de un programa informático para estudiar resting states dinámicos en IRM

Celis-Alonso, B. de; Moreno-Barbosa, E.; Martínez, Mafla; González-Gómez, Difariney; Hidalgo-Tobón, S.; Dies-Suárez, Pilar; Barragán-Pérez, Eduardo

doi:10.1016/s2214-3106(15)30062-5

Cited by 1 publication

(8 citation statements)

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“…20 volunteers is not a large sample, but it is comparable to samples used for other publications in the field (e.g. (30,40,41)). Samples this size have been shown to have enough statistical power to show significant results (42).…”

Section: B) Volunteersmentioning

confidence: 81%

“…Volunteers were instructed not to move during the fMRI scan, especially their noses and mouths, to reduce motion artifacts in the results. A detailed explanation of this paradigm is provided in recent research from this group (30).…”

Section: C) Paradigmmentioning

confidence: 99%

“…Image analysis of this data was identical to the methodology described in previous work from this group, (30,40,41). Briefly, BOLD-fMRI data was preprocessed with the CONN toolbox (49).…”

Section: E) Software and Image Analysismentioning

confidence: 99%

“…The values selected here are standard values, common to other publications in the field (e.g. (30,41)). Images were presented using the Viewer option of the DPARSFA software (50), in which fMRI-calculated t-maps were overlaid on anatomical MNI brain templates, using the statistical threshold mentioned.…”

Section: Smoothing With a Gaussian Kernel 3 Times The Size Of The Voxels (Fwhm)mentioning

confidence: 99%

“…MR techniques are widely used to study neurological disorders (e.g. (30,33,34)); nevertheless, work linking impulsivity and odor is sparse, even when olfaction is considered to be a precursor or modulator of addictive and impulsive behaviors, (35,36). Lesions to the orbitofrontal cortex related to impulsive aggressive disorders have shown to make patients anosmic (37).…”

Section: Introductionmentioning

confidence: 99%

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Lisdexamfetamine Alters BOLD-fMRI Activations Induced by Odor Cues in Impulsive Children

Tobón

Suárez

Pérez

et al. 2020

CNSNDDT

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Introduction: Lisdexamfetamine (LDX) is a drug used to treat ADHD/impulsive patients. Impulsivity is known to affect inhibitory, emotional and cognitive function. On the other hand, smell and odor processing are known to be affected by neurological disorders, as they are modulators of addictive and impulsive behaviors specifically. We hypothesize that, after LDX ingestion, inhibitory pathways of the brain would change, and complementary behavioral regulation mechanisms would appear to regulate decision-making and impulsivity. Methods: 20 children were studied in an aleatory crossover study. Imaging of BOLD-fMRI activity, elicited by olfactory stimulation in impulsive children, was performed after either LDX or placebo ingestion. Results: Findings showed that all subjects that underwent odor stimulation presented activations of similar intensities in the olfactory centers of the brain. This contrasted with inhibitory regions of the brain such as the cingulate cortex and frontal lobe regions, which demonstrated changed activity patterns and intensities. While some differences between the placebo and medicated states were found in motor areas, precuneus, cuneus, calcarine, supramarginal, cerebellum and posterior cingulate cortex, the main changes were found in frontal, temporal and parietal cortices. When comparing olfactory cues separately, pleasant food smells like chocolate seemed not to present large differences between the medicated and placebo scenarios, when compared to non-food-related smells. Conclusions: We demonstrated that LDX, first, altered the inhibitory pathways of the brain, second, increased activity in large amounts of brain regions which were not activated by smell in drug-naïve patients, third, facilitated a complementary behavioral regulation mechanism, run by the cerebellum, which regulated decision-making and impulsivity in motor and frontal structures.

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Section: B) Volunteersmentioning

confidence: 81%

Section: C) Paradigmmentioning

confidence: 99%

“…Image analysis of this data was identical to the methodology described in previous work from this group, (30,40,41). Briefly, BOLD-fMRI data was preprocessed with the CONN toolbox (49).…”

Section: E) Software and Image Analysismentioning

confidence: 99%

Section: Smoothing With a Gaussian Kernel 3 Times The Size Of The Voxels (Fwhm)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lisdexamfetamine Alters BOLD-fMRI Activations Induced by Odor Cues in Impulsive Children

Tobón

Suárez

Pérez

et al. 2020

CNSNDDT

View full text Add to dashboard Cite

show abstract

09C: Desarrollo de un programa informático para estudiar resting states dinámicos en IRM

Cited by 1 publication

References 2 publications

Lisdexamfetamine Alters BOLD-fMRI Activations Induced by Odor Cues in Impulsive Children

Lisdexamfetamine Alters BOLD-fMRI Activations Induced by Odor Cues in Impulsive Children

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