Abstract:Glucocorticoids (GCs) regulate skin homeostasis and combat cutaneous inflammatory diseases, however, adverse effects of chronic GC treatments limit their therapeutic use.GCs bind and activate the GC receptor (GR) and the mineralocorticoid receptor (MR), transcription factors that recognize identical hormone responsive elements (HREs).Whether epidermal MR mediates beneficial or deleterious GC effects is of great interest for improving GC-based skin therapies. MR epidermal knock-out (MR EKO ) mice exhibited incr… Show more
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