0825 The Effect of Androgen Deprivation Therapy on Insomnia Symptoms, Fatigue, Mood, and Hot Flashes in Men with Non-Metastatic Prostate Cancer

Wijk, Megan Van; Garland, Sheila N.; Wall, Kayla; Sathya, Jinka; Thoms, John

doi:10.1093/sleep/zsz067.823

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whilst there are at least two main prospective studies that have considered the impact of ADT on sleep problems [16,17], and a further study investigating ADT with radiation therapy [9], none has used actigraphy in their clinical assessment. The current study showed that sleep disturbances were higher for the cohort of patients on ADT compared with those who were ADT naïve (70% vs. 40%).…”

Section: Discussionmentioning

confidence: 99%

“…Sleep disturbances may arise following radical prostatectomy or radiation therapy [6]. Androgen Deprivation Therapy (ADT), which is widely employed in both metastatic and locally advanced prostate cancer, is highly associated with poor sleep and this is likely to be related to nocturnal hot flashes and/or the loss of androgen [7][8][9]. In practice, however, sleep issues are rarely assessed, diagnosed, and treated, as compared with the more recognizable longer-term side effects such as osteoporosis, cardiovascular and diabetic complications associated with ADT.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluating Patterns and Factors Related to Sleep Disturbances in Prostate Cancer Patients

Mondal¹,

Edwards

Wibowo

et al. 2022

Healthcare

View full text Add to dashboard Cite

Prostate cancer patients may experience disturbed sleep as a result of their diagnosis or treatment. This study sought to evaluate disturbed sleep and excessive daytime sleepiness in newly diagnosed patients and those receiving androgen deprivation therapy (ADT). This study was conducted with 74 patients. Subjective data using the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) and actigraphy data on ADT/ADT-naïve patients were collected. The prevalence of poor sleep quality, determined from PSQI and ESS scores, was 50% and 16.7% respectively. Those on ADT (n = 20) had poorer sleep quality as determined by significantly higher PSQI scores (70 vs. 40% scoring > 5) and were more likely to have poor sleep quality, sleep latency, and sleep efficiency than ADT-naïve patients (n = 40). Actigraphy data showed that ADT patients slept significantly longer (7.7 vs. 6.8 h), experienced a higher Fragmentation Index (48.3 vs. 37.4%), and had longer daytime nap duration (64.1 vs. 45.2 min) than ADT-naïve patients. The use of objective measures such as actigraphy in the clinical arena is recommended and may be used as a valuable tool for research into sleep assessment in prostate cancer patients.

show abstract

Section: Discussionmentioning

confidence: 99%