0758 Reduced Spindle Frequency and Density in Stage 2 Nrem Sleep Is Associated With Increased CSF P-Tau in Cognitively Normal Elderly

Sharma, Ram A.; Kam, Korey; Parekh, Ankit; Uribe-Cano, Santiago; Tweardy, Samuel; Bubu, O M; Ayappa, Indu; Rapoport, D.; Varga, AW; Osorio, RS

doi:10.1093/sleepj/zsx050.757

Cited by 3 publications

(2 citation statements)

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“…Poor sleep correlates with Aβ and tau pathology severity among people with AD and MCI (38)(39)(40)(41)(42), and recent studies indicate associations between AD pathology and NREM sleep (40,43). Recently, Fultz et al (44) simultaneously measured functional magnetic resonance imaging (fMRI) studies measuring blood-oxygenation-level-dependent (BOLD) signals, electroencephalogram (EEG) and cerebrospinal fluid (CSF) and observed that at 0.05 Hz (SO that occurs during NREM sleep), there was a large-amplitude pulsatile flow of CSF.…”

Section: Sleep Brain Activity and Brain Pathologymentioning

confidence: 99%

Intermittent Light Exposures in Humans: A Case for Dual Entrainment in the Treatment of Alzheimer's Disease

Figueiro

Leggett

2021

Front. Neurol.

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Circadian sleep disorders are common among American adults and can become especially acute among older adults, especially those living with Alzheimer's disease (AD) and mild cognitive impairment (MCI), leading to the exacerbation of symptoms and contributing to the development and advancement of the diseases. This review explores the connections between circadian sleep disorders, cognition, and neurodegenerative disease, offering insights on rapidly developing therapeutic interventions employing intermittent light stimuli for improving sleep and cognition in persons with AD and MCI. Light therapy has the potential to affect sleep and cognition via at least two pathways: (1) a regular and robust light-dark pattern reaching the retina that promotes circadian phase shifting, which can promote entrainment and (2) 40 Hz flickering light that promotes gamma-wave entrainment. While this is a new area of research, preliminary evidence shows the potential of dual circadian and gamma-wave entrainment as an important therapy not only for those with AD, but for others with cognitive impairment.

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Section: Sleep Brain Activity and Brain Pathologymentioning

confidence: 99%

Intermittent Light Exposures in Humans: A Case for Dual Entrainment in the Treatment of Alzheimer's Disease

Figueiro

Leggett

2021

Front. Neurol.

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“…35,36 In patients with ADRD and MCI, as well as in cognitively normal older adults, poor sleep correlates with the severity of A and tau pathology, [39][40][41][42][43] and recent studies show selective associations between slow oscillations (SOs) 44 and sleep spindles 45 (which both play a key role in memory consolidation) and ADRD pathology. 41,46 A clearance through the glymphatic system occurs during sleep, 38 providing a mechanism linking sleep disturbance and accumulation of brain A. Crucially, sleep is a potentially modifiable factor that can be enhanced to counteract memory decline and the continued progression to ADRD.…”

Section: Adrd and Sleep Disturbancesmentioning

confidence: 99%

Lighting and Alzheimer’s disease and related dementias: Spotlight on sleep and depression

Figueiro

Kales

2021

Lighting Research & Technology

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Alzheimer’s disease and related dementias is the collective term for a progressive neurodegenerative disease for which there is presently no cure. This paper focuses on two symptoms of the disease, sleep disturbances and depression, and discusses how light can be used as a non-pharmacological intervention to mitigate their negative effects. Bright days and dark nights are needed for health and well-being, but the present components of the built environment, especially those places where older adults spend most of their days, are too dimly illuminated during the day and too bright at night. To be effective light needs to be correctly specified, implemented and measured. Yet, without the appropriate specification and measurement of the stimulus, researchers will not be able to successfully demonstrate positive results in the field, nor will lighting designers and specifiers have the confidence to implement lighting solutions for promoting better sleep and mood in this population.

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Impact of sex steroids and reproductive stage on sleep-dependent memory consolidation in women

Baker

Sattari

Zambotti

et al. 2019

Neurobiology of Learning and Memory

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Age and sex are two of the three major risk factors for Alzheimer's disease (ApoE-e4 allele is the third), with women having a twofold greater risk for Alzheimer's disease after the age of 75 years. Sex differences have been shown across a wide range of cognitive skills in young and older adults, and evidence supports a role for sex steroids, especially estradiol, in protecting against the development of cognitive decline in women. Sleep may also be a protective factor against age-related cognitive decline, since specific electrophysiological sleep events (e.g. sleep spindle/slow oscillation coupling) are critical for offline memory consolidation. Furthermore, studies in young women have shown fluctuations in sleep events and sleep-dependent memory consolidation during different phases of the menstrual cycle that are associated with the levels of sex steroids. An under-appreciated possibility is that there may be an important interaction between these two protective factors (sex steroids and sleep) that may play a role in daily fluctuations in cognitive processing, in particular memory, across a woman's lifespan. Here, we summarize the current knowledge of sex steroid-dependent influences on sleep and cognition across the lifespan in women, with special emphasis on sleep-dependent memory processing. We further indicate gaps in knowledge that require further experimental examination in order to fully appreciate the complex and changing landscape of sex steroids and cognition. Lastly, we propose a series of testable predictions for how sex steroids impact sleep events and sleep-dependent cognition across the three major reproductive stages in women (reproductive years, menopause transition, and post-menopause).

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0758 Reduced Spindle Frequency and Density in Stage 2 Nrem Sleep Is Associated With Increased CSF P-Tau in Cognitively Normal Elderly

Cited by 3 publications

References 0 publications

Intermittent Light Exposures in Humans: A Case for Dual Entrainment in the Treatment of Alzheimer's Disease

Intermittent Light Exposures in Humans: A Case for Dual Entrainment in the Treatment of Alzheimer's Disease

Lighting and Alzheimer’s disease and related dementias: Spotlight on sleep and depression

Impact of sex steroids and reproductive stage on sleep-dependent memory consolidation in women

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