0712 Socio-Economic and Demographic Factors influencing Sleep Duration in Women

Bandyopadhyay, Anuja; Slaven, James E.; Rohr-Kirchgraber, Theresa; Manchanda, Shalini

doi:10.1093/sleep/zsy061.711

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“…Co‐variates were chosen a priori from the literature on the basis of their potential to confound the relationship between sleep and dementia 8,36–38 . Variables assumed to potentially contribute to the development of dementia and related to sleep disturbances, such as cardiovascular diagnoses, were not adjusted for because of the possibility of being on the causal pathway.…”

Section: Methodsmentioning

confidence: 99%

Longitudinal association of apolipoprotein E and sleep with incident dementia

Palpatzis

Bass

Jones

et al. 2021

Alzheimer's & Dementia

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Introduction:Few longitudinal studies have explored the association between apolipoprotein E gene (APOE) status, sleep disturbances, and incident dementia among middle-aged participants.Methods: Cox regression analyses explored the association of sleep duration, insomnia, and daytime napping with incident all-cause dementia and their interaction with APOE genetic risk among 397,777 middle-aged adults.Results: During a median of 10.8 years follow-up, sleeping more or fewer than 7 hours was associated with a higher dementia risk (hazard ratio [HR] for 5 vs 7 hours: 1.35, 95% confidence interval [CI] 1.11-1.64; HR for 9 vs 7 hours: 1.59; 95% CI 1.37-1.85) as was daytime napping (HR for often/all of the time vs never/rarely: 1.67; 95% CI 1.37-2.03). Stratified analyses revealed that the effects of sleep disturbances were similar across all APOE genetic risk groups. Discussion: Short and long sleep duration and daytime napping in middle-aged individuals are associated with the development of dementia in later life. Sleep duration and quality are important for everyone regardless of their genetic risk by APOE genotype.

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Section: Methodsmentioning

confidence: 99%