069 Effects of dietary β-glucan on growth performance, diarrhea, and gut permeability of weanling pigs experimentally infected with a pathogenic Escherichia coli

Kim, K.; Ehrlich, A; Perng, Vivian; Chase, Jennifer; Raybould, Helen E.; Li, X.; Atwill, Edward R.; Whelan, Rose; Sokale, Adebayo; Liu, Y.

doi:10.2527/asasann.2017.069

Cited by 2 publications

(4 citation statements)

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“…In the current study, F18 E. coli infection was accomplished in agreement with our previous studies using an E. coli challenge model in weaned piglets (9,12). According to Kim et al (31), heat-labile toxin and Shiga toxin induce gut permeability and inflammation, which, in turn, increase cytokines.…”

Section: Discussionsupporting

confidence: 79%

“…It would be possible that increased expression of CLDN-1 in ileal mucosa fortified the intestinal barrier function in pigs fed STB infected with E. coli. TNFα is a crucial pro-inflammatory cytokine in reaction to an infection by bacteria which is produced by neutrophils (31). IL-6 is also a pro-inflammatory cytokine expressed widely across vertebrates and plays multiple physiological roles involved in inflammation (37).…”

Section: Discussionmentioning

confidence: 99%

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Effects of stimbiotic supplementation on gut health, immune response, and intestinal microbiota in weaned piglets challenged with E. coli

et al. 2023

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In order to make piglet diets more effective, it is necessary to investigate effective methods for breaking down xylan in cereal. The objective of this study was to determine the effects of dietary stimbiotic (STB) supplementation on growth performance, intestinal morphology, immune response and intestinal microbiota in weaned piglets. A total of 24 (Duroc × Yorkshire × Landrace) weaned pigs (initial body weight of 8.01 ± 0.38 kg and 28 ± 3 d old), were assigned to 4 treatments with 6 replicates per treatment. Pigs were housed in individual pens for 17 days, including 5 days adaption period and 12 days after the first Escherichia coli (E. coli) challenge. The experiment was conducted in a 2 × 2 factorial arrangement of treatments consisting of two levels of challenge (challenge and non-challenge) and two levels of STB (0 and 0.5 g/kg diet). Supplementations of STB 0.5 g/kg improved the gain to feed ratio (G:F) (P < 0.05) in piglets challenged with shiga toxigenic E. coli (STEC). STB supplementation decreased (P < 0.05) white blood cells, neutrophils, lymphocytes, and expression levels of tumor necrosis factor-alpha and interleukin-6. Supplementation of STB improved (P < 0.05) the lymphocytes and neutrophils in piglets challenged with STEC on 12 dpi. Supplementation of STB also improved (P < 0.05) the villus height to-crypt depth ratio of ileum in piglets challenged with STEC. Supplementation of STB increased (P < 0.05) the expression levels of claudin-1 of ileum. In genus level, supplementation of STB increased (P < 0.001) the abundance of Prevotella compared to non-supplementation of STB groups in pre-inoculation period. Also, supplementation of STB decreased (P < 0.05) the abundance of Faecalibacterium and Eubacterium_coprostanoligenes_group compared to non-supplementation of STB groups in post-inoculation period. In phylum level, supplementation of STB increased (P < 0.05) the abundance of Desulfobacterota and Fibrobacterota in pre-inoculation period. E. coli challenge increased the abundance of Fibrobacterota compared to non-challenged group in post-inoculation period. In conclusion, these findings indicated that STB supplementation could alleviate a decrease of the performance, immune response, and inflammatory response in piglets induced by the STEC challenge.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Effects of stimbiotic supplementation on gut health, immune response, and intestinal microbiota in weaned piglets challenged with E. coli

et al. 2023

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“…These findings align with previous research [ 37 ], which noted an enhancement in feed conversion ratios with β-glucan supplementation. The pivotal role of β-glucans in promoting gut health has been well emphasized [ 41 ]. β-glucans contribute to maintaining the integrity of the gut barrier and support the establishment of a healthy gut microbiome [ 41 ], which is critical for preventing post-weaning diarrhea.…”

Section: Yeast-derived β-Glucans: Enhancing Swine Nutrition and Healt...mentioning

confidence: 99%

“…The pivotal role of β-glucans in promoting gut health has been well emphasized [ 41 ]. β-glucans contribute to maintaining the integrity of the gut barrier and support the establishment of a healthy gut microbiome [ 41 ], which is critical for preventing post-weaning diarrhea. Additionally, β-glucans also have the potential to alleviate weaning stress in pigs [ 40 ].…”

Section: Yeast-derived β-Glucans: Enhancing Swine Nutrition and Healt...mentioning

confidence: 99%

Nutritional Strategies to Mitigate Post-Weaning Challenges in Pigs: A Focus on Glucans, Vitamin D, and Selenium

O’Doherty,

Dowley,

Conway

et al. 2023

Animals

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This review examines the challenges faced by the pig industry, with a specific focus on improving the health and growth of weaned pigs. It emphasizes the immediate necessity of investigating alternative approaches to managing pig nutrition and health due to restrictions on the use of antibiotics and the prohibition of zinc oxide in weaned pig diets. The weaning phase is identified as a critical stage in piglet development, characterized by stressors that affect their gastrointestinal health, immune responses, and overall physiology. The primary challenge during weaning arises from transitioning piglets from a digestible milk-based diet to a less digestible cereal-based feed, causing nutritional stress. This manifests as reduced feed intake, leading to gastrointestinal disturbances, intestinal inflammation, and adverse effects on intestinal structure and microbiota. To address these challenges and optimize piglet development, various nutritional strategies have been explored. Notably, glucans, particularly β-glucans from fungi, cereals, algae, and yeast, show promise in alleviating weaning-related issues. Furthermore, it is important to highlight the critical roles played by Vitamin D and selenium in piglet nutrition. These essential nutrients can be sourced naturally from enriched mushrooms that are specifically enriched with Vitamin D and selenium, providing a sustainable dietary option. In conclusion, effective nutritional strategies, including glucans, Vitamin D, selenium, and enriched mushrooms, are beneficial for addressing weaning-related challenges.

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069 Effects of dietary β-glucan on growth performance, diarrhea, and gut permeability of weanling pigs experimentally infected with a pathogenic Escherichia coli

Cited by 2 publications

References 0 publications

Effects of stimbiotic supplementation on gut health, immune response, and intestinal microbiota in weaned piglets challenged with E. coli

Effects of stimbiotic supplementation on gut health, immune response, and intestinal microbiota in weaned piglets challenged with E. coli

Nutritional Strategies to Mitigate Post-Weaning Challenges in Pigs: A Focus on Glucans, Vitamin D, and Selenium

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