066 Epidemiology of Sepsis-Associated Acute Kidney Injury (Sa-Aki) Requiring Renal Replacement Therapy (Rrt) in a Secondary Hospital in Malaysia - A Single Centre Study

Abstract

Among the group who had hypoperfusion, 94.4% were post cardiac surgery, of which 84.9% had cyanotic congenital heart disease. Treatment with peritoneal dialysis occurred in intensive care unit in 93.8% of the patients. It is associated with mechanical ventilation in 92.1%, use of two or more inotropes in 85.3% and two or more organ dysfunction in 71.2%. The indications for peritoneal dialysis were fluid overload(60.5%), uraemia and fluid overload(26.6%), uraemia(11.9%) and others(1.7%). Technique failure occurred in 1.1% of the patients and they were switched to haemodialysis. Mortality in our PD cohort was 30.5%. Age, weight, gender and primary aetiology of AKI were not significant risk factors of death. At hospital discharge, mean serum creatinine was 47.6(CI 34.3-60.9)mcmol/ L and estimated glomerular filtration rate(eGFR) was 89.7(CI 78.5-100.9) mls/min/1.73m 2. 10% of the patients had eGFR less than 60mls/min/m 2. None of the survivors developed end stage renal failure at hospital discharge. Conclusions: PD offers good patient survival and renal outcome as evidenced in our cohort. Hence, PD is a viable first line renal replacement therapy in severe AKI for young children with low body weight even if they are critically ill.