0657 the Circadian Variant of Idiopathic Hypersomnia

Rj, Thomas; Naik, Sreelatha

doi:10.1093/sleepj/zsx050.656

Cited by 6 publications

(6 citation statements)

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“…These results are in concordance with the finding of a phase delay in the rhythm of melatonin and cortisol secretions in 15 patients with IH ( 29 ). Clinical findings like sleep inertia and sleep drunkenness, which are often reported by IH patients, indicate an altered homeostatic regulation of the sleep wake cycle of the patients ( 30 ), which might also be linked to an aberrant circadian rhythm and a long biological night ( 31 ). Focusing on the endogenous circadian regulation, this study shows for the first time a prolonged circadian period length in fibroblasts of patients suffering from IH.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Hypersomnia Patients Revealed Longer Circadian Period Length in Peripheral Skin Fibroblasts

et al. 2018

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The vast majority of living organisms have evolved a circadian rhythm of roughly 24 h in adaptation to ever-changing environmental conditions, such as the cycle of light and darkness. In some sleep disorders like idiopathic hypersomnia (IH) this adaptation is defective. As the etiology of this disease is largely unknown, we examined the in vitro circadian period length of patients suffering from IH. The patients were diagnosed according to the ICSD3-criteria by clinical history, polysomnography (PSG), and multiple sleep latency testing (MSLT). In order to gain insight into the molecular mechanism of this sleep disorder we collected fibroblasts from skin biopsies of IH patients and healthy subjects. We determined the circadian period length of the primary fibroblast cells by lentiviral infection with a construct expressing a luciferase gene under the control of a BMAL1 promoter. The group of IH patients revealed on average a prolonged circadian period length. In comparison to the group of healthy controls (HC) the mean period length was estimated to be 0.82 h (95%-CI 0.44–1.20 h) longer in the patient group. This finding further stresses a disturbed regulation of the circadian rhythm in IH patients as part of the pathophysiology of this complex and poorly understood primary sleep disorder.

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Section: Discussionmentioning

confidence: 99%

Idiopathic Hypersomnia Patients Revealed Longer Circadian Period Length in Peripheral Skin Fibroblasts

et al. 2018

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“…More recently, urine melatonin metabolites were measured in patients with IH. 50 A long biological night was demonstrated at 16 ± 1.2 hours. Of note, the biological night was normal at 9 hours or less in 10 patients, possibly in relation with the presence of both patients with IHwLST and with IHwoLST in the sample.…”

Section: Critical Review Of Icsd-3 Clinical and Electrophysiological ...mentioning

confidence: 96%

“…[44][45][46][47][48] Circadian control tests, melatonin and cortisol, have value supporting the diagnosis of IHwLSD. 49,50 Currently, neuroimaging, [51][52][53] expression of key circadian proteins in dermal fibroblasts [54][55][56] and measure of an endogenous positive allosteric modulator of GABA-A in the CSF 57 cannot yet be considered as helpful in the diagnosis of IH (Table 2).…”

Section: Second Step: Diagnosis Of Ihmentioning

confidence: 99%

Idiopathic Hypersomnia: Historical Account, Critical Review of Current Tests and Criteria, Diagnostic Evaluation in the Absence of Biological Markers and Robust Electrophysiological Diagnostic Criteria

Billiard¹,

Šonka²

2022

NSS

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Idiopathic hypersomnia was first described in 1976 under two forms: polysymptomatic, characterized by excessive daytime sleepiness, long and unrefreshing naps, nocturnal sleep of abnormally long duration and signs of sleep drunkenness upon awakening; monosymptomatic, manifested by excessive daytime sleepiness only. Yet, after 45 years, this sleep disorder is still poorly delineated and diagnostic criteria produced by successive International Classifications of Sleep Disorders are far from satisfactory. The first part of this review is a historical account of the successive names and descriptions of idiopathic hypersomnia: monosymptomatic and polysymptomatic idiopathic hypersomnia in 1976; central nervous system idiopathic hypersomnia in 1979; idiopathic hypersomnia in 1990; idiopathic hypersomnia with and without long sleep time in 2005; idiopathic hypersomnia again in 2014; and, within the last few years, the proposal of separating idiopathic hypersomnia into a well-defined subtype, idiopathic hypersomnia with long sleep duration, and a more heterogeneous subtype combining idiopathic hypersomnia without long sleep duration and narcolepsy type 2. The second part is a critical review of both current ICSD-3 diagnostic criteria and clinical features, scales and questionnaires, electrophysiological and circadian control tests, research techniques, currently used to diagnose idiopathic hypersomnia. The third part proposes a diagnostic evaluation of idiopathic hypersomnia, in the absence of biologic markers and of robust electrophysiological diagnostic criteria.

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“…Hypersomnia can be a symptom of circadian rhythm disorders, especially when a person's sleep and wake patterns are disturbed. 5 Circadian rhythm disorders are disorders that affect a person's body's natural rhythm, which regulates sleeping, waking, and other activities in a cycle of approximately 24 hours. This disorder can cause a person to sleep at unusual times or have difficulty maintaining normal sleep patterns.…”

Section: Circadian Rhythm Disordersmentioning

confidence: 99%

“…As a result, they may experience excessive sleepiness and hypersomnia when they want to be awake and active. 4,5…”

Section: Circadian Rhythm Disordersmentioning

confidence: 99%

Neurotransmitter Related Idiopathic Hypersomnia

Muhammad,

Patricia Wulandari

2021

SciPsy

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Idiopathic hypersomnia affects 5% of the adult population, and both men and women are equally susceptible. Excessive sleep, sleep attacks, or wake-time delays are all examples of primary hypersomnia. Hypersomnia can be caused by a mental disorder, an organic condition (such as medications), or it might be idiopathic. This condition is the polar opposite of insomnia. Patients are frequently misdiagnosed as having mental illnesses or being sluggish. Hypersomnia patients require more sleep than the average person. The patient will generally sleep 1-2 times each day, with each nap lasting more than an hour. Despite the fact that they sleep a lot, they are usually weary and sluggish during the day. The causes of hypersomnia can be diverse, including neurological, medical, or psychological disorders. Neurotransmitters can also play a role in regulating a person's sleep patterns and alertness. This review aimed to describe neurotransmitters related to idiopathic hypersomnia.

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0657 the Circadian Variant of Idiopathic Hypersomnia

Cited by 6 publications

References 0 publications

Idiopathic Hypersomnia Patients Revealed Longer Circadian Period Length in Peripheral Skin Fibroblasts

Idiopathic Hypersomnia Patients Revealed Longer Circadian Period Length in Peripheral Skin Fibroblasts

Idiopathic Hypersomnia: Historical Account, Critical Review of Current Tests and Criteria, Diagnostic Evaluation in the Absence of Biological Markers and Robust Electrophysiological Diagnostic Criteria

Neurotransmitter Related Idiopathic Hypersomnia

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