0623 Increased Risk for Cancer in Young Patients With Severe Obstructive Sleep Apnea

Brenner, Ronen; Kivity, Shaye; Peker, Marina; Reinhorn, Daniel; Keinan‐Boker, Lital; Silverman, Barbara; Liphshiz, Irena; Kolitz, Tamara; Shlomi, Dekel; Peled, Nir; Pillar, Giora

doi:10.1093/sleepj/zsx050.622

Cited by 4 publications

(2 citation statements)

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“…In the Australian Brusselton Sleep Cohort, people with moderate to severe sleep apnea had an elevated risk of mortality, cancer, and stroke compared with those without (90). In another cohort there was an increased risk of cancer in young patients (Ͻ45 yr of age) with severe sleep apnea (19).…”

Section: Cancer Incidencementioning

confidence: 99%

Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer

Hunyor

Cook

2018

American Journal of Physiology-Regulatory, Integrative and Comp

109

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Obstructive sleep apnea (OSA) is common and linked to a variety of poor health outcomes. A key modulator of this disease is nocturnal intermittent hypoxia. There is striking epidemiological evidence that patients with OSA have higher rates of cancer and cancer mortality. Small-animal models demonstrate an important role for systemic intermittent hypoxia in tumor growth and metastasis, yet the underlying mechanisms are poorly understood. Emerging data indicate that intermittent hypoxia activates the hypoxic response and inflammatory pathways in a manner distinct from chronic hypoxia. However, there is significant heterogeneity in published methods for modeling hypoxic conditions, which are often lacking in physiological relevance. This is particularly important for studying key transcriptional mediators of the hypoxic and inflammatory responses such as hypoxia-inducible factor (HIF) and NF-κB. The relationship between HIF, the molecular clock, and circadian rhythm may also contribute to cancer risk in OSA. Building accurate in vitro models of intermittent hypoxia reflective of OSA is challenging but necessary to better elucidate underlying molecular pathways.

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Section: Cancer Incidencementioning

confidence: 99%

Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer

Hunyor

Cook

2018

American Journal of Physiology-Regulatory, Integrative and Comp

109

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“…Recently, a great number of researches have explored the correlation between OSA and other diseases. Multiple investigations and meta-analyses have illustrated that OSA poses a threat to human health because it increases the risk of various diseases, including cancers [15][16][17], depression [18], laryngopharyngeal reflux disease [19], metabolic disease [20], Parkinson's disease [21], and chronickidney disease (CKD) [22].…”

Section: Introductionmentioning

confidence: 99%

An umbrella review of systematic reviews and meta-analyses of observational investigations of obstructive sleep apnea and health outcomes

Chen

Guo

et al. 2021

Sleep Breath

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Purpose The previous analysis of systematic reviews and meta-analyses have illustrated that obstructive sleep apnea (OSA) is correlated with multiple health outcomes. In the present research, our main aim was to execute an umbrella review to assess the available evidence for the associations between OSA and health outcomes. Methods Herein, a meta-analysis of previous observational investigations that have reported associations between OSA and health outcomes in all human populations and settings was performed. We used these studies to execute an umbrella review of available meta-analyses and systematic reviews. Results Sixty-six articles comprising 136 unique outcomes were enrolled in this analysis. Of the 136 unique outcomes, 111 unique outcomes had significant associations (p < 0.05). Only 7 outcomes (coronary revascularization after PCI, postoperative respiratory failure, steatosis, alaninetrans aminase (ALT) elevation, metabolic syndrome (MS), psoriasis, and Parkinson’s disease) had a high quality of evidence. Twenty-four outcomes had a moderate quality of evidence, and the remaining 80 outcomes had a weak quality of evidence. Sixty-nine outcomes exhibited significant heterogeneity. Twenty-five outcomes exhibited publication bias. Sixty-three (95%) studies showed critically low methodological quality. Conclusion Among the 66 meta-analyses exploring 136 unique outcomes, only 7 statistically significant outcomes were rated as high quality of evidence. OSA may correlate with an increased risk of coronary revascularization after PCI, postoperative respiratory failure, steatosis, ALT elevation, MS, psoriasis, and Parkinson’s disease.

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Obstructive Sleep Apnea and Colorectal Cancer: A Systematic Review and Meta-Analysis

Niranjan

Sriram

Gopalan

2023

J Gastrointest Canc

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0623 Increased Risk for Cancer in Young Patients With Severe Obstructive Sleep Apnea

Cited by 4 publications

References 0 publications

Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer

Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer

An umbrella review of systematic reviews and meta-analyses of observational investigations of obstructive sleep apnea and health outcomes

Obstructive Sleep Apnea and Colorectal Cancer: A Systematic Review and Meta-Analysis

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