056. serum Transforming Growth Factor-B in Takayasu Arteritis – A Clue for a Potential Failure of This Anti- Inflammatory Pathway in Arterial Inflammation?

Savioli, Bruna; Salu, Bruno Ramos; Brito, Marlon de; Oliva, Maria Luiza Vilela; Souza, Alexandre Wagner de

doi:10.1093/rheumatology/kez057.055

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“…TGFB1 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins, a profibrotic cytokine in M2 (Cui et al, 2020). Compared the TGF-β level in serum of TA patients and healthy control and drew a conclusion that TGF-β is lower in TA, especially active TA (Savioli et al, 2020). It demonstrated that TGF-β is a potential biomarker of disease activity assessment.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome profiling of abdominal aortic tissues reveals alterations in mRNAs of Takayasu arteritis

Miao

Gao

et al. 2022

Front. Genet.

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Takayasu arteritis (TA) is a chronic granulomatous vasculitis involving in the main branches of aorta. Previous studies mainly used peripheral blood and some vascular tissues but seldom studies have sequenced vascular tissues. Here in this study, we aimed to explore the alterations of mRNA in TA by performing bulk RNA sequencing. A total of 14 abdominal aortic tissues including 8 from renal transplantation and 6 from patient with TA undergoing bypass surgeries. Bulk RNA sequencing were performed and after the quality control, a total of 1897 transcripts were observed to be significantly differently (p < 0.05 and Log2FC > 1) expressed between the TA and control group, among which 1,361 transcripts were in TA group and 536 in the Control group. Reactome Pathway Enrichment Comparison analysis revealed interleukin-10 signaling and signaling by interleukins were highly expressed in TA group. Besides, extracellular matrix organization was also observed in this group. WGCNA and PPI obtained 26 core genes which were highly correlated with the clinical phenotype. We then also perform deconvolution of the bulk RNA-seq data by using the scRNA-seq dataset and noticed the high proportion of smooth muscle cells in our dataset. Additionally, immunohistochemical staining confirmed our bioinformatic analysis that TA aortic tissues express high levels of IL-1R1 and IL-1R2. Briefly, this study revealed critical roles of interleukins in TA pathogenesis, and SMCs may also participate in the reconstruction in vessel wall at late stage of TA.

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Section: Discussionmentioning

confidence: 99%