0410: Cardiovascular manifestations in antiphospholipid syndrome

Salem, T. Ben; Salem, Wafa Ben; Khatib, Maria; Tougorti, M.; Ghorbel, I. Ben; Lamloum, M.; Houman, M.H.

doi:10.1016/s1878-6480(16)30107-0

Cited by 1 publication

(15 citation statements)

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“…Antisynthetase syndrome was reported in 2 studies. 41,51 In the largest series of IIMs, the frequency of ASS was 2.9%, and ASS overlapped with (unspecified) CTDs in 2 of the 3 affected patients. 51 A case series from Tunisia also reported 9 cases of ASS retrieved within a 15-year period (2000-2014) in an internal medicine department.…”

Section: Antisynthetase Syndromementioning

confidence: 90%

“…Hypomyopathic and amyopathic subtypes of ASS were reported in 2 and 1 of these patients, respectively. 41 Other subtypes of IIMs including IMNM and IBM were not reported.…”

Section: Antisynthetase Syndromementioning

confidence: 99%

“…The frequency of joint involvement (defined by the presence of arthralgia with or without synovitis) ranged from 28% in the aforementioned study on JDM from South Africa 36 to 100% in the ASS case series. 41 Autoantibodies were recorded in 13 studies 20,25,26,29,30,32,33,36,41,45,48,50,51 (Supplementary Table S11, http://links.lww.com/ RHU/A286). The frequency of positive serum anti-Jo1/histidyl-tRNA synthetase antibodies varied between 0 (of 6 patients tested) in the aforementioned study on JDM from South Africa 36 and 100% (of 2 patients tested) in the study from Senegal involving 21 subjects.…”

Section: Key Disease Features Of Iimsmentioning

confidence: 99%

“…51 An elevated serum titer of anti-PL12/alanyl-tRNA synthetase antibodies was also recorded in 1 of 9 patients with ASS-associated ILD in the case series from Tunisia. 41 Other myositis-specific antibodies (MSAs) were not described. Out of the MSAs, the most frequently reported serum autoantibodies were antinuclear antibodies, found in 17.4% of patients in the study from Kenya 48 and 100% (out of 6 patients tested) in the latter study from Tunisia.…”

Section: Key Disease Features Of Iimsmentioning

confidence: 99%

“…Major muscular and cutaneous signs were reported in 16 studies, 14,16,18,[20][21][22]25,26,30,32,34,36,41,44,48,51 as detailed in Table 2. The frequency of proximal muscle weakness varied between 0 in a study from Tunisia involving 1 subject with AJDM 22 and 100% in the aforementioned study from Kenya, which reported on DM/JDM/PM/CAM.…”

Section: Key Disease Features Of Iimsmentioning

confidence: 99%

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Epidemiology of Idiopathic Inflammatory Myopathies in Africa

et al. 2021

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Background:The epidemiology of idiopathic inflammatory myopathies (IIMs) has been extensively studied in America, Europe, and Asia, but remains unclear in Africa.Objective: The aim of this review was to summarize available data on the epidemiology of IIMs in Africa. Methods:We searched MEDLINE, EMBASE, and African Journals Online for studies published up to December 30, 2020, and reporting epidemiological data on IIMs in Africa. Data were combined through narrative synthesis. The review protocol was registered with PROSPERO, CRD42020186781. Results:We included 39 studies reporting 683 cases (71.7% adults) of IIMs. Incidence rates of ~7.5/1,000,000 person-years and 1.2/1,000,000 person-years were estimated for dermatomyositis (DM), whereas polymyositis (PM) had an incidence rate of 8.8/1,000,000 person-years. Prevalence estimates of 11.49/100,000 and 11/100,000 (95% confidence interval, 0-32) were provided for IIMs and the PM subtype, respectively. Mean age at diagnosis ranged from 7.9 to 57.2 years, and 50% to 100% of the patients were females. Main subtypes of adult-onset IIMs were DM (21%-93%) and PM (12%-79%), whereas the commonest juvenile subtype was juvenile DM (5.8%-9%). Skeletal muscle involvement (56%-100%) was the main disease feature, and esophagus was the most commonly affected internal organ (6%-65.2%). Anti-Jo1/histidyl tRNA synthetase (7%-100%) and anti-Mi2 (17%-45%) antibodies were the most frequent myositis specific antibodies. Early mortality was high (7.8%-45%), and main death causes were infections, cancers and organ damage in respiratory and cardiovascular domains.Conclusions: Apart from a potential younger age at onset of adult IIMs in Africa, current sparse data mostly suggest a similar epidemiology between Africa and other regions. Further high-quality studies are required to validate these findings.

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Section: Antisynthetase Syndromementioning

confidence: 90%

“…Hypomyopathic and amyopathic subtypes of ASS were reported in 2 and 1 of these patients, respectively. 41 Other subtypes of IIMs including IMNM and IBM were not reported.…”

Section: Antisynthetase Syndromementioning

confidence: 99%