04.11 Hypoxia and rheumatoid phenotype prevent synovial fibroblasts from suppressing t helper cell proliferation through ido1-mediated tryptophan metabolism
Abstract:BackgroundThe development of rheumatoid arthritis (RA) is linked to changes in synovial fibroblasts’ (SF) phenotype and local infiltration of immune cells. In addition, hypoxic conditions are detected within the inflamed joints of RA patients. The oxygen level in RA joints is only about 22,5mmHg corresponding to ambient oxygen tensions of 3.2%. Right now there is not much known about the effect of hypoxia on the interaction between fibroblasts and immune cells and its implications on the pathophysiology of RA.… Show more
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