038 — (LIM0157) Evaluation of effects of the standardized extract of Justicia pectoralis (chamba) in the pilocarpine model of seizure and antioxidant effect in the hippocampus of mice

Lima, Klistenes Alves de; Venâncio, Edith Teles; Linhares, Maria Isabel; Souza, Alana Gomes de; Silva, A.H.; Leal, Luzia Kalyne Almeida Moreira; Fonteles, M.M.F.

doi:10.1016/j.yebeh.2014.08.071

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Positive results in either model suggest that the test compound, or its metabolite crossed the blood–brain barrier and exerted its effect in the central nervous system [ 1 ]. In this review, all experiments consisted initially of phenotypic screens in rodents using predominantly PTZ [ 6 , 13 , 18 , 19 , 21 , 22 , 24 , 25 , 27 , 28 ], MES [ 20 , 22 , 24 ] and pilocarpine [ 16 , 23 , 26 , 32 ] seizure models. A few researchers dared to test their extracts in more than one phenotypic screening models [ 13 , 20 , 22 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed from this review, most experimenters implicate potentiation of GABA-ergic activity as the mode of action of their extracts [ 18 - 20 , 24 , 27 , 30 ]. Others notably implicate the cholinergic system [ 23 ], antioxidants [ 25 ] and AMPA receptors [ 26 ]. As earlier stated, the limited range of models used limit to discovery to only me-too drugs.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Antiepileptic Herbal Medicine

Manchishi

2017

View full text Add to dashboard Cite

Background:Epilepsy is one of the most common neurological disorders worldwide, with about 80 percent of cases thought to be in developing nations where it is mostly linked to superstition. The limited supply, high cost as well as low efficacy and adverse side effects of antiepileptic drugs (AEDs) is a matter of major concern. Herbal medicine has always been traditionally part of treatment of epilepsy. Herbal medicines are generally well tolerated, with fewer side effects.Method:To highlight some herbal extracts that have been studied for their anticonvulsant activity in animal models, literature search from PubMed and Science Direct, was performed. The keywords for the search consisted of combinations of the following terms: Herbal antiepileptic and/or anticonvulsant, botanicals + epilepsy. Literature published in the last five years was considered.Results:Eighteen (18) anticonvulsant herbal agents are reported and discussed. Experiments mostly consisted of phenotypic screens in rodents, with little diversity in screening methods. In most experiments, the tested extracts prolonged the time to onset of seizures and decreased their duration. Most experimenters implicate potentiation of GABAergic activity as the mode of action of the extracts, even though some experimenters did not fully characterise the bioactive chemical composition of their extracts.Conclusion:Potential herbal remedies have shown positive results in animal models. It remains unclear how many make it into clinical trials and eventually making part of the AED list. More rigorous research, applying strict research methodology with uniform herbal combinations, as well as clinical studies are urgently needed.

show abstract