032 An Evolving Hypothesis on the Mechanism and Efficacy of Intracavernosal Injection of Botulinum Toxin to Improve Erectile Function: an Animal Study in Aging Rats

Intra‐cavernous injection of BOTOX® (50 and 100 Units) for treatment of vasculogenic erectile dysfunction: Randomized controlled trial

“…There are only three preclinical animal studies that investigated the effect of ICI of Botox in rates of different species and ages. The results of these preclinical studies concluded that BTX improves erectile function in aging rats proclaimed by increased intra‐cavernosal pressure 20‐22 and increased sinusoidal volume in BTX‐treated treatment groups compared to control ( p < 0.001). These effects led to the enhancement of cavernosal smooth muscle relaxation and increased penile blood flow during sexual stimulation 20,22 …”

“…[15][16][17] Previous studies found that SARS, 1 of the 3 epidemic coronaviruses to emerge in the past 20 years and that shows similar clinical presentations to COVID-19, 18 could cause orchitis 19 and focal testicular atrophy. 20 Considering the tens of millions of COVID-19 cases and that men are more vulnerable to COVID-19 than women, [21][22][23] it is imperative to determine the effect of COVID-19 on male reproduction. 24 Several studies have been performed on this topic.…”