This chapter describes DySCAS: an advanced autonomic platform-independent middleware framework for automotive embedded systems. The concepts and architecture are motivated and described in detail, focusing on the need for, and achievement of, high flexibility and automatic run-time reconfiguration. The design of the middleware is positioned with respect to the way it overcomes the specific technical, environmental, and performance challenges of the automotive domain. Self-management is achieved in terms of automatic configuration for context-aware behavior, resource-use efficiency, and self-healing to handle run-time detected faults. The self-management is governed by the use of policies distributed throughout the middleware components. The simulation techniques that have been used for extensive validation are described and some key results presented. A reference implementation is presented, illustrating the way in which the various concepts and mechanisms can be realized and orchestrated.