0218 Optogenetic Manipulation of Parvalbumin Containing Gabaergic Neurons in the Thalamic Reticular Nucleus Alters Declarative and Non-Declarative Memories in Mice

Katsuki, Fumi; McNally, JM; Thankachan, Stephen; McKenna, JT; Brown, Ritchie E.; Strecker, R E; McCarley, R.W.

doi:10.1093/sleepj/zsx050.217

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Disruption of WFA1 PNN rhythms in subjects with schizophrenia may contribute to sleep spindle and memory consolidation deficits in several ways. WFA1 PNNs regulate firing rates of neurons expressing PVB, including those in the TRN that generate sleep spindles (Csillik et al, 2005;Katsuki et al, 2017). Furthermore, decreases of PVB neurons were detected in the TRN of subjects with schizophrenia (Steullet et al, 2018).…”

Section: Implications For Psychiatric Disordersmentioning

confidence: 99%

Circadian Rhythms of Perineuronal Net Composition

Pantazopoulos

Gisabella

Rexrode

et al. 2020

eNeuro

View full text Add to dashboard Cite

Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that envelop neurons and regulate synaptic functions. Long thought to be stable structures, PNNs have been recently shown to respond dynamically during learning, potentially regulating the formation of new synapses. We postulated that PNNs vary during sleep, a period of active synaptic modification. Notably, PNN components are cleaved by matrix proteases such as the protease cathepsin-S. This protease is diurnally expressed in the mouse cortex, coinciding with dendritic spine density rhythms. Thus, cathepsin-S may contribute to PNN remodeling during sleep, mediating synaptic reorganization. These studies were designed to test the hypothesis that PNN numbers vary in a diurnal manner in the rodent and human brain, as well as in a circadian manner in the rodent brain, and that these rhythms are disrupted by sleep deprivation. In mice, we observed diurnal and circadian rhythms of PNNs labeled with the lectin Wisteria floribunda agglutinin (WFA1 PNNs) in several brain regions involved in emotional memory processing. Sleep deprivation prevented the daytime decrease of WFA1 PNNs and enhances fear memory extinction. Diurnal rhythms of cathepsin-S expression in microglia were observed in the same brain regions, opposite to PNN rhythms. Finally, incubation of mouse sections with cathepsin-S eliminated PNN labeling. In humans, WFA1 PNNs showed a diurnal rhythm in the amygdala and thalamic reticular nucleus (TRN). Our results demonstrate that PNNs vary in a circadian manner and this is disrupted by sleep deprivation. We suggest that rhythmic modification of PNNs may contribute to memory consolidation during sleep.

show abstract

Section: Implications For Psychiatric Disordersmentioning

confidence: 99%

Circadian Rhythms of Perineuronal Net Composition

Pantazopoulos

Gisabella

Rexrode

et al. 2020

eNeuro

View full text Add to dashboard Cite

show abstract

“…Circadian rhythms in PNN composition may also impact sleep spindles in SZ. PNN PNNs regulate firing rates of neurons expressing parvalbumin (PVB), including those in the thalamic reticular nucleus (TRN) that generate sleep spindles (Csillik et al, 2005;Katsuki et al, 2017;Latchoumane et al, 2017;Fernandez et al, 2018;Thankachan et al, 2019). Decreases of PNNs and PVB neurons were detected in the TRN of subjects with schizophrenia (Steullet et al, 2017).…”

Section: Schizophreniamentioning

confidence: 99%

Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules

et al. 2021

View full text Add to dashboard Cite

Sleep disturbances and memory dysfunction are key characteristics across psychiatric disorders. Recent advances have revealed insight into the role of sleep in memory consolidation, pointing to key overlap between memory consolidation processes and structural and molecular abnormalities in psychiatric disorders. Ongoing research regarding the molecular mechanisms involved in memory consolidation has the potential to identify therapeutic targets for memory dysfunction in psychiatric disorders and aging. Recent evidence from our group and others points to extracellular matrix molecules, including chondroitin sulfate proteoglycans and their endogenous proteases, as molecules that may underlie synaptic dysfunction in psychiatric disorders and memory consolidation during sleep. These molecules may provide a therapeutic targets for decreasing strength of reward memories in addiction and traumatic memories in PTSD, as well as restoring deficits in memory consolidation in schizophrenia and aging. We review the evidence for sleep and memory consolidation dysfunction in psychiatric disorders and aging in the context of current evidence pointing to the involvement of extracellular matrix molecules in these processes.

show abstract

“…Disruption of WFA+ PNN rhythms in subjects with schizophrenia may contribute to sleep spindle and memory consolidation deficits in several ways. WFA+ PNNs regulate firing rates of neurons expressing parvalbumin (PVB), including those in the TRN that generate sleep spindles (Csillik et al, 2005;Katsuki et al, 2017). Furthermore, decreases of PVB neurons were detected in the TRN of subjects with schizophrenia (Steullet et al, 2017).…”

Section: Implications For Psychiatric Disordersmentioning

confidence: 99%

Circadian Rhythms of Perineuronal Net Composition

Pantazopoulos

Gisabella

Rexrode

et al. 2020

Preprint

View full text Add to dashboard Cite

Perineuronal Nets (PNNs) are extracellular matrix (ECM) structures that envelop neurons and regulate synaptic functions. Long thought to be stable structures, PNNs have been recently shown to respond dynamically during learning, potentially regulating the formation of new synapses. We postulated that PNNs may vary during sleep, a period of active synaptic modification. Notably, PNN components are cleaved by matrix proteases such as the protease cathepsin-S, synthesized by microglia. Cathepsin-S is expressed in a diurnal manner in the mouse cortex, coinciding with dendritic spine density rhythms. Thus, cathepsin-S may induce PNN remodeling during sleep, mediating synaptic reorganization. These studies were designed to test the hypothesis that PNN numbers vary in a diurnal manner in the rodent and human brain, and in a circadian manner in the rodent brain, in association with cathepsin-S expression rhythms coinciding with reported rhythms in synaptic plasticity. In mice, we observed diurnal and circadian rhythms of PNNs labeled with the lectin wisteria floribunda agglutinin (WFA+PNNs) in several brain regions involved in emotional memory processing. Sleep deprivation prevented the daytime decrease of WFA+ PNNs. Diurnal rhythms of cathepsin-S expression in microglia were observed in the same brain regions, opposite to PNN rhythms. Finally, incubation of mouse sections with cathepsin-S eliminated PNN labeling. In humans, WFA+PNNs showed a diurnal rhythm in the amygdala and thalamic reticular nucleus (TRN). Our results demonstrate that PNNs vary in a circadian manner that coincides with expression rhythms of cathepsin-S in the mouse hippocampus. We suggest that rhythmic modification of PNNs may contribute to memory consolidation during sleep.

show abstract

0218 Optogenetic Manipulation of Parvalbumin Containing Gabaergic Neurons in the Thalamic Reticular Nucleus Alters Declarative and Non-Declarative Memories in Mice

Cited by 3 publications

References 0 publications

Circadian Rhythms of Perineuronal Net Composition

Circadian Rhythms of Perineuronal Net Composition

Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules

Circadian Rhythms of Perineuronal Net Composition

Contact Info

Product

Resources

About