020 Human exercise induced circulating progenitor cell mobilisation is nitric oxide dependent and is blunted in South Asian men

Cubbon, R; Murgatroyd, Scott R.; Ferguson, Carrie; Bowen, T. Scott; Rakobowchuk, Mark; Baliga, Vivek; Cannon, Daniel T.; Rajwani, Adil; Abbas, Afroze; Kahn, Morton C.; Birch, Karen M.; Porter, Karen E.; Wheatcroft, S; Rossiter, Harry B.; Kearney, Mark T.

doi:10.1136/hrt.2010.195941.20

Cited by 3 publications

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“…The mobilization of progenitor cells, which is NO dependent, [22] A limitation could be that most patients with chronic coronary artery disease who meet the inclusion criteria were men but the gender distribution is, in the population of our hospital, similar to that included in the study. Mobilization of progenitor cells could also be depending on exercise intensity suggesting a physiological stimulus to improve oxygen delivery via increased capillary network in the exercise above anaerobic threshold.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise

Gagliardi¹,

Maciel

Castellano

et al. 2016

Thrombosis Research

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Section: Accepted Manuscriptmentioning

confidence: 99%

Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise

Gagliardi¹,

Maciel

Castellano

et al. 2016

Thrombosis Research

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Changes in Circulating Stem and Progenitor Cell Numbers Following Acute Exercise in Healthy Human Subjects: a Systematic Review and Meta-analysis

Schmid

Kröpfl

Spengler

2021

Stem Cell Rev and Rep

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Despite of the increasing number of investigations on the effects of acute exercise on circulating stem and progenitor cell (SC) numbers, and in particular on respective subgroups, i.e. endothelial (ESC), hematopoietic (HSC), and mesenchymal (MSC) stem and progenitor cells, a consensus regarding mechanisms and extent of these effects is still missing. The aim of this meta-analysis was to systematically evaluate the overall-effects of acute exercise on the different SC-subgroups and investigate possible subject- and intervention-dependent factors affecting the extent of SC-mobilization in healthy humans. Trials assessing SC numbers before and at least one timepoint after acute exercise, were identified in a systematic computerized search. Compared to baseline, numbers were significantly increased for early and non-specified SCs (enSCs) until up to 0.5 h after exercise (0–5 min: +0.64 [Standardized difference in means], p < 0.001; 6–20 min: +0.42, p < 0.001; 0.5 h: +0.29, p = 0.049), for ESCs until 12–48 h after exercise (0–5 min: +0.66, p < 0.001; 6–20 min: +0.43 p < 0.001; 0.5 h: +0.43, p = 0.002; 1 h: +0.58, p = 0.001; 2 h: +0.50, p = 0.002; 3–8 h: +0.70, p < 0.001; 12–48 h: +0.38, p = 0.003) and for HSCs at 0–5 min (+ 0.47, p < 0.001) and at 3 h after exercise (+ 0.68, p < 0.001). Sex, intensity and duration of the intervention had generally no influence. The extent and kinetics of the exercise-induced mobilization of SCs differ between SC-subpopulations. However, also definitions of SC-subpopulations are non-uniform. Therefore, finding a consensus with a clear definition of cell surface markers defining ESCs, HSCs and MSCs is a first prerequisite for understanding this important topic. Graphical Abstract

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Óxido nítrico e exercício: uma revisão

Souza¹,

Asano

Prestes³

et al. 2012

R. Educ. Fís. UEM

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RESUMOO óxido nítrico (NO) é um potente vasodilatador com papel importante no controle do tônus vascular. Estudos têm demonstrado a função do NO na preservação da capacidade funcional do endotélio, prevenindo aterosclerose, lesão vascular, hipertensão, entre outras. Por outro lado, fatores genotípicos e/ou fenotípicos podem diminuir sua biodisponibilidade, resultando em disfunção endotelial grave, e aumentar a resistência vascular periférica. Recentes estudos têm demonstrado que o exercício aumenta a biodisponibilidade do NO de forma aguda e crônica. Porém, a produção do conhecimento relacionado ao NO, mediado pelo exercício, ainda apresenta lacunas. Neste sentido, o objetivo desta revisão é tentar elucidar os mecanismos celulares envolvidos na síntese e regulação do NO e demonstrar o avanço do conhecimento cientifico relacionado à biodisponibilidade de NO mediado pelo exercício. Para tanto, para esta revisão foram utilizados livros e periódicos das bases de dados PubMed, HIGWIRE, SciELO e LILACS, utilizando as palavras-chave "nitric oxide" e "exercise" para a busca de publicações. As principais considerações do estudo foram que o exercício físico pode aumentar a biodisponibilidade de NO de forma aguda, e as adaptações crônicas do exercício em relação aos parâmetros cardiovasculares são dependentes do aumento da biodisponibilidade de NO induzida pelo exercício.

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020 Human exercise induced circulating progenitor cell mobilisation is nitric oxide dependent and is blunted in South Asian men

Cited by 3 publications

References 0 publications

Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise

Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise

Changes in Circulating Stem and Progenitor Cell Numbers Following Acute Exercise in Healthy Human Subjects: a Systematic Review and Meta-analysis

Óxido nítrico e exercício: uma revisão

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