Abstract:BackgroundRheumatoid arthritis (RA) is characterised by the activation of auto-reactive T-cells and the development of auto-antibodies. Importantly, T-cells may additionally respond to non-TCR mediated signals, which are essential in driving their effector functions. Pathways leading to the modulation of both innate and adaptive signals are therefore of marked interest to study in arthritis.The paracaspase MALT1 is a key player in the activation of lymphoid, myeloid and mast cells, indicating MALT1’s crucial r… Show more
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