0080 TBI Time Since Injury: A Comparison Model Between Sleep Efficiency and Neurocognitive Performance

Abstract

Introduction MTBI remains on one of the most prevalently reported brain injuries. Previous studies have shown an association between sleep efficiency, performance, and neurocognitive outcome. Reported time-since-injury (TSI) has also shown an association with neurocognitive outcome measures, with some evidence suggesting neurocognitive status is significantly worse at 2 weeks post-injury. Here, we examined differences in self-reported sleep efficiency at various time points since injury among individuals who had sustained an mTBI in the preceding year. Methods 190 Participants [71 male, 119 female], age M=24.48, SD=6.80 (HC, n=39) and five mild TBI groups based on time post-injury, 2-weeks (2W, n=12), 1-month (1M, n=30), 3-months (3M, n=34), 6-months (6M, n=33), and 12-months (12M, n=40) post-injury. Participants completed a cross-sectional study at specific post-injury time points ranging from (2W, 1M, 3M, 6M, 12M). Participants completed comprehensive Repeatable Battery for Neuropsychological Status (RBANS) and were administered the Pittsburg Sleep Quality Index (PSQI) at the time of assessment. Here we analyzed the sleep efficiency subscale of the PSQI. Separate correlation analysis examined the association between sleep efficiency and the attention index for each TSI group. Results The ANOVA showed a main effect of TSI group, F(5,182) = 2.83, p=.017. Post Hoc comparisons with the LSD test showed that the 12M group had worse sleep ­efficiency than HC and 2W, 1M, and 3M but did not differ from 6M (p<.05). Separate correlations between sleep efficiency and the attention index of the RBANS for each TSI group showed a marginally significant association at 2W (r(10)=-.467, p=.063, one tailed), and statistically significant at 12M (r(38)=-.266, p=.049, one tailed), suggesting that worse sleep efficiency was associated with worse attention performance at those time points. Conclusion Sleep efficiency differs across the first year of recovery from mTBI. Notably, individuals in the 12M TSI group appear to have worse sleep efficiency than any other TSI group but did not differ from the 6M group. Sleep efficiency appears to be associated with attentional capacity at 2W and 12M timeframes. This suggests that interventions that focus on enhancing sleep in patients with mTBI may prove promising for facilitating recovery. Support (if any) W81XWH-12-1-0386