0021 Sleep Deprivation Activates Nlrp3 Inflammasomes in Neurons and Glia

Niznikiewicz, M M; Gerashchenko, Dmitry; McKenna, JT; Basheer, Radhika; Strecker, R E; McCarley, R.W.; Zielinski,

doi:10.1093/sleepj/zsx050.020

Cited by 2 publications

(3 citation statements)

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“…Therefore, we can speculate that a higher expression level of IL-1β may cause more severe insomnia and higher degree of liver depression in PNSD patients. Animal experimental studies have found that high levels of oxidative stress and expression of IL-1β in the brain tissue of sleep-deprived animals (22,23). IL-1β is a well-known sleep-regulating cytokine (24).…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum IL‑1β and insomnia and liver depression in patients with perimenopausal non‑organic sleep disorder

Chen

Wu³

et al. 2018

Exp Ther Med

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The aim of the study was to detect the expression of interleukin-1β (IL-1β) in serum of patients with perimenopausal non-organic sleep disorder (PNSD) and to study the relationship between IL-1β and the severity of insomnia and liver depression, so as to benefit the prevention of PNSD. A total of 268 cases of perimenopausal patients from the Department of Traditional Chinese Medicine of Fujian Provincial Hospital and the Department of Traditional Chinese Medicine of Jinshan Branch of Fujian Provincial Hospital were selected from March 2014 to June 2017. Among them, 182 patients developed non-organic insomnia (observation group). The remaining 86 patients were included in the control group. Serum levels of IL-1β were measured by enzyme-linked immunosorbent assay (ELISA). Scores of liver depression were determined and graded. Pittsburgh Sleep Quality Index (PSQI) was used to assess the severity of insomnia. Spearman's correlation analysis was used to analyze the correlation between PSQI, IL-1β and liver depression grade. Scores of liver depression in the observation group were significantly higher than those in control group (p<0.05). In the observation group, and PSQI scores in patients with different grades of liver depression are significantly different (p<0.05). Average level of IL-1β in the observation group was significantly higher than that in control group (p<0.05). With the increase of liver depression grade, the expression level of IL-1β was also increased (p<0.05). Spearman's correlation analysis showed that PSQI was positively correlated with liver depression score, and the level of IL-1β was positively correlated with the liver depression grade in patients with PNSD. (r=0.724, p=0.012; r=0.765, p=0.008). Expression of IL-1β in women with PNSD is significantly upregulated, and different degrees of liver depression also exist. Higher expression level of IL-1β is accompanied by more serious liver depression and higher degree of insomnia.

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Section: Discussionmentioning

confidence: 99%

Relationship between serum IL‑1β and insomnia and liver depression in patients with perimenopausal non‑organic sleep disorder

Chen

Wu³

et al. 2018

Exp Ther Med

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“…(Smith et al, 2019) 7 SD activates the NLRP3 inflammasome in neurons, astrocytes, and microglia, although this activation varies depending upon the brain area. (Niznikiewicz et al, 2017) 8…”

Section: # Findings Referencesmentioning

confidence: 99%

“…For instance, we know that insufficient sleep stimulates the NLRP3 inflammasome in neurons, microglia, and astrocytes. However, different effects have been observed depending on the involved portion of the brain ( Niznikiewicz et al, 2017 ). The effects of NLRP3 inflammasome have been reported in the hippocampal region, but its effects have not yet been explored in other brain areas and thus remain unknown.…”

Section: Role Of Nlrp3 Inflammasome In Sd-induced Neuroinflammationmentioning

confidence: 99%

Sleep deprivation and NLRP3 inflammasome: Is there a causal relationship?

et al. 2022

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In the modern era, sleep deprivation (SD) is one of the most common health problems that has a profound influence on an individual’s quality of life and overall health. Studies have identified the possibility that lack of sleep can stimulate inflammatory responses. NLRP3 inflammasome, a key component of the innate immune responses, initiates inflammatory responses by enhancing proinflammatory cytokine release and caspase-1-mediated pyroptosis. In this study, NLRP3 modification, its proinflammatory role, and potential targeted therapies were reviewed with regard to SD-induced outcomes. A growing body of evidence has showed the importance of the mechanistic connections between NLRP3 and the detrimental consequences of SD, but there is a need for more clinically relevant data. In animal research, (i) some animals show differential vulnerability to the effects of SD compared to humans. (ii) Additionally, the effects of sleep differ depending on the SD technique employed and the length of SD. Moreover, paying attention to the crosstalk of all the driving factors of NLRP3 inflammasome activation such as inflammatory responses, autonomic control, oxidative stress, and endothelial function is highly recommended. In conclusion, targeting NLRP3 inflammasome or its downstream pathways for therapy could be complicated due to the reciprocal and complex relationship of SD with NLRP3 inflammasome activation. However, additional research is required to support such a causal claim.

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0021 Sleep Deprivation Activates Nlrp3 Inflammasomes in Neurons and Glia

Cited by 2 publications

References 0 publications

Relationship between serum IL‑1β and insomnia and liver depression in patients with perimenopausal non‑organic sleep disorder

Relationship between serum IL‑1β and insomnia and liver depression in patients with perimenopausal non‑organic sleep disorder

Sleep deprivation and NLRP3 inflammasome: Is there a causal relationship?

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