0.1% Tacrolimus Ointment for the Treatment of Intertrigo

Chapman, Michael; Brown, Joanne; Linowski, Gregory J.

doi:10.1001/archderm.141.6.787-a

Cited by 10 publications

(10 citation statements)

References 3 publications

(1 reference statement)

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“…Twice-daily application of tacrolimus 0.1% ointment has been shown to be effective in clearing patients of intertrigo and may prove beneficial for long-term treatment because of the lack of atrophy and striae with use. 137 Candidal superinfection is best treated with topical antifungal agents. Systemic antifungal therapy may be required in some patients.…”

Section: Intertrigomentioning

confidence: 99%

Obesity and the skin: Skin physiology and skin manifestations of obesity

Yosipovitch

DeVore²,

Dawn³

2007

Journal of the American Academy of Dermatology

429

309

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Section: Intertrigomentioning

confidence: 99%

Obesity and the skin: Skin physiology and skin manifestations of obesity

Yosipovitch

DeVore²,

Dawn³

2007

Journal of the American Academy of Dermatology

429

309

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“…Accordingly, the final set for data extraction and analyses consisted of 70 references, representing 68 studies (the two manuscripts of Chapman [ 16 , 17 ] and the two of Spector [ 18 , 19 ] are respectively discussed as a single study). The flow of the inclusion process is depicted in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…All studies concerned the treatment of existing intertrigo and mainly the treatment of intertrigo lesions that were already infected (n = 40). In only three studies was it explicitly stated that the research concerned intertrigo that was not yet infected [ 16 , 25 , 26 ]. In the remaining studies the phase/severity of the intertrigo was not clear.…”

Section: Resultsmentioning

confidence: 99%

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Prevention and treatment of intertrigo in large skin folds of adults: a systematic review

Mistiaen

Halm-Walters²

2010

BMC Nurs

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BackgroundIntertrigo in the large skin folds is a common problem. There is a plethora of treatments, but a lack of evidence about their efficacy. A nursing guideline on this matter had to be updated and broadened in scope to other health care professionals.MethodsA systematic review was performed. Thirteen databases were sensitively searched, supplemented by reference tracking and forward citation searches. All types of empirical research relating to the prevention or treatment of intertrigo were included. Study selection, assessment of bias, data-extraction and analysis were done by two independent review-authors.ResultsSixty-eight studies fulfilled the inclusion criteria. Only 4 studies were RCTs and even these had a considerable risk of bias. Study populations were generally small.No studies were found about the prevention of intertrigo. The therapies concerned mostly the topical application of antimycotics, corticosteroids, antibiotics, antiseptics or a combination of these. Besides these pharmaceutical interventions, surgical breast reduction was also studied. Although most study-authors were positive, we could not draw firm conclusions about any of the pharmaceutical interventions. Even patients that received placebo intervention showed improvement. There is weak evidence that reduction mammaplasty may be helpful to treat inframammary intertrigo. All research found had considerable risk of bias, prohibiting firm conclusions.ConclusionsThere is no evidence at all about the prevention of intertrigo and there is no firm evidence about its treatment. Well designed studies are needed.

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“…This condition often misdiagnosed as tinea pedis or eczematous dermatitis. In some patients, the macerated eruption is unresponsive to treatment with antibacterial agents, antifungals or antiinflammatory agents 9 . Therefore, clinical and microbiological studies are suggested to assist in the selection of appropriate treatment and prevention of important complications 10 .…”

Section: Discussionmentioning

confidence: 99%

A Bacteriological Study of Intertrigo

Rao¹,

Vasimalli²,

Gowda³

et al. 2018

J Pure Appl Microbiol

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The study was taken up to identify the various bacterial agents causing intertrigo of feet and to determine the antimicrobial sensitivity pattern of the isolated bacterial agents. A total of 75 pus samples were collected from infected toe, web space infection by using sterile swabs.Samples were inoculated into Blood agar and MacConkey agar for the bacterial isolation and antibiotic susceptibility testing was performed as per CLSI Guidelines. Out of 75 samples examined 38 were from male patients and 37 were collected from female patients. 101 different types of bacteria were grown in the present study. Among them38 Gram-PositiveCocci (GPC) and 63 Gram-Negative Bacilli (GNB). Of 38 Gram positive cocci isolated, Staphylococcus aureuswere19 (18.81%), followed by Coagulase negative staphylococcus (CONS) 12 (11.88%) and Streptococcus spp7 (6.93%). Of 63 Gram negative bacilli isolated Pseudomonas were19 (18.81%), followed by Proteus 16 (15.84%) and Klebsiella13 (12.87%). 25.8% Staphylococcus sppare Methecillin Resistant (MR) strains. Among the Gram negative bacteria 9.25% of the strains were showing resistance to Colistin or Tigecycline. It is known fact that different microbes and factors play very important role in lesions of toe web space. In the present study 25.8% of Staphylococcus species and 9.25% of Gram negative bacteria were multi drug resistant.Therefore, clinical and microbiologic studies are needed to help in the selection of appropriate treatment, prevention of important complications and emergence of drug resistance pathogens.

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0.1% Tacrolimus Ointment for the Treatment of Intertrigo

Cited by 10 publications

References 3 publications

Obesity and the skin: Skin physiology and skin manifestations of obesity

Obesity and the skin: Skin physiology and skin manifestations of obesity

Prevention and treatment of intertrigo in large skin folds of adults: a systematic review

A Bacteriological Study of Intertrigo

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