Aim. To study the adaptation reactions of the hemostasis system to hypercapnic hypoxia of maximum intensity in rats subjected to preliminary multiple exposure to ethylmethylhydroxypyridine succinate and hypercapnic hypoxia of submaximal intensity. Methods. In the experiment, Wistar male rats (80 individuals) were used. Training cycles: 30-fold daily exposure to hypercapnic hypoxia of submaximal intensity (20 minutes — 9.0±0.5% O2, 7.0±0.5% CO2); administration of ethylmethylhydroxypyridine succinate (50 mg/kg) to animals for 30 days; combined effects of the two described modes. Tested experimental exposure was simulated as a single hypercapnic hypoxia of maximum intensity (20 minutes — 5.0±0.5% O2, 5.0±0.5% CO2) at the end of each of three 30-day training cycles. Results. Preliminary 30-day exposure to both isolated hypercapnic hypoxia of submaximal intensity and combined exposure to ethylmethylhydroxypyridine succinate contributes to hypocoagulation shift in the hemostasis system and reduces the level of the markers of pre-thrombotic state in response to a single hypercapnic hypoxia of maximum intensity. The state of the hemostasis system after 30-day cycle of isolated use of an antihypoxant is characterized by the inhibition of the vascular-platelet system of the hemostasis system and preserved hypercoagulation shifts in its plasma unit. The obtained results suggest that both preliminary isolated effect of hypercapnic hypoxia of submaximal intensity and the combined effect of hypercapnic hypoxia and ethylmethylhydroxypyridine succinate increase the resistance of the hemostasis system in experimental animals to acute hypercapnic hypoxia of maximum intensity compared to rats of the control group. This was confirmed by the inhibition of the vascular-platelet system, hypocoagulation in the plasma unit, decrease in the level of thrombotic readiness markers and increase in the anticoagulant activity of the blood system compared to the control. At the same time, isolated course administration of ethylmethylhydroxypyridine succinate did not cause the same amount of adaptive changes to maximum intensity hypercapnic hypoxia, since only platelet suppression of the hemostasis and hypocoagulation via the internal coagulation pathway were registered. Conclusion. Isolated exposure of hypercapnic hypoxia of submaximal intensity and its combined exposure with ethylmethylhydroxypyridine succinate increase the resistance of the hemostasis system to acute hypercapnic hypoxia of maximum intensity; isolated course administration of ethylmethylhydroxypyridine succinate does not cause the same amount of adaptive changes.
Aim. To investigate the specific features of stress reactivity and diagnostic potential of psycho-emotional tests for identification of the patients with workplace arterial hypertension (WPAH). Material ad methods. The study included 197 patients with WPAH and 132 subjects with essential AH (EAH). All participants underwent blood pressure monitoring (BPM) during work and leisure hours and stress reactivity assessment (count test). Results. In WPAH and EAH patients, the count test resulted in increased systolic (SBP), diastolic (DBP) BP, and heart rate (HR) (р<0,001), which was an evidence of stress-related functional cardiovascular reaction. In subjects with new-onset WPAH, compared to EAH patients, the SBP and HR increases were greater by 7,9 mm Hg (р<0,005) and 4,3 bpm (р<0,001), respectively. In patients with long-term EAH, SBP increase was greater by 3,4 mm Hg (p=0,03), with a halved HR increase (p<0,001). In healthy controls and AH patients, the differences between baseline levels of SBP and DBP, peak levels during the count test, and BMP levels for work hours were comparable. Conclusion. The patients at early WPAH stages were characterized by increased cardiovascular reaction to acute induced psycho-emotional stress. At the later WPAH stages, BP reactivity was reduced. The cont test could be used as a screening tool in patients with undiagnosed WPAH.
Цель. Оценить частоту признаков электрической нестабильности сердца у лиц стрессовых профессий путем комплексной оценки показателей клиникофункциональных методов исследования. Материал и методы. Обследовано 154 мужчин с АГ I-II стадии; первую группу составили 78 машинистов и помощников машинистов локомотивов, имеющие стрессовую профессию, вторую группу-76 лиц с минимальным психоэмоциональным напряжением. Проводилось клинико-функциональное обследование. Результаты. В 1-й группе "возможное наличие" поздних потенциалов предсердий и желудочков было в 2 раза чаще (p=0,0001) и в 3 раза (p=0,0002), соответственно, по сравнению со 2-й группой. Ригидный циркадный индекс в 1-й группе встречался чаще в 1,7 раза (Х 2 =10,5; p<0,001), чем во 2-й. Среди лиц, имеющих сочетание АГ и хронического гастрита или язвенную болезнь желудка и ДПК, ригидность циркадного индекса встречалась в 1,6 раза (x 2 =5,9; p<0,05) чаще в 1-й группе, чем во 2-й. При АГ I стадии у лиц 1-й группы чаще выявляется смещение коэффициента вагосимпатического баланса в сторону гиперсимпатикотонии по сравнению со 2-й. Заключение. Таким образом, у молодых мужчин с АГ и профессиональным стрессом по сравнению с мужчинами низкострессовой профессии, чаще выявляются признаки электрической нестабильности миокарда.
Aim. To study the adaptation reactions of the hemostasis system to hypercapnic hypoxia of maximum intensity in rats subjected to preliminary multiple exposure to ethylmethylhydroxypyridine succinate and hypercapnic hypoxia of submaximal intensity. Methods. In the experiment, Wistar male rats (80 individuals) were used. Training cycles: 30-fold daily exposure to hypercapnic hypoxia of submaximal intensity (20 minutes — 9.0±0.5% O2, 7.0±0.5% CO2); administration of ethylmethylhydroxypyridine succinate (50 mg/kg) to animals for 30 days; combined effects of the two described modes. Tested experimental exposure was simulated as a single hypercapnic hypoxia of maximum intensity (20 minutes — 5.0±0.5% O2, 5.0±0.5% CO2) at the end of each of three 30-day training cycles. Results. Preliminary 30-day exposure to both isolated hypercapnic hypoxia of submaximal intensity and combined exposure to ethylmethylhydroxypyridine succinate contributes to hypocoagulation shift in the hemostasis system and reduces the level of the markers of pre-thrombotic state in response to a single hypercapnic hypoxia of maximum intensity. The state of the hemostasis system after 30-day cycle of isolated use of an antihypoxant is characterized by the inhibition of the vascular-platelet system of the hemostasis system and preserved hypercoagulation shifts in its plasma unit. The obtained results suggest that both preliminary isolated effect of hypercapnic hypoxia of submaximal intensity and the combined effect of hypercapnic hypoxia and ethylmethylhydroxypyridine succinate increase the resistance of the hemostasis system in experimental animals to acute hypercapnic hypoxia of maximum intensity compared to rats of the control group. This was confirmed by the inhibition of the vascular-platelet system, hypocoagulation in the plasma unit, decrease in the level of thrombotic readiness markers and increase in the anticoagulant activity of the blood system compared to the control. At the same time, isolated course administration of ethylmethylhydroxypyridine succinate did not cause the same amount of adaptive changes to maximum intensity hypercapnic hypoxia, since only platelet suppression of the hemostasis and hypocoagulation via the internal coagulation pathway were registered. Conclusion. Isolated exposure of hypercapnic hypoxia of submaximal intensity and its combined exposure with ethylmethylhydroxypyridine succinate increase the resistance of the hemostasis system to acute hypercapnic hypoxia of maximum intensity; isolated course administration of ethylmethylhydroxypyridine succinate does not cause the same amount of adaptive changes.
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