Purpose: Transcutaneous electrical neural stimulation (TENS), as a non-invasive modality, has been clinically used as an alternative treatment for children with overactive bladder (OAB). We conducted a pooled analysis to explore the effect of TENS on OAB.Methods: The Preferred Reporting Items for Systematic Reviews and Meta-analysis guideline was followed in this study. The MEDLINE, Embase, and Cochrane Central Register of Controlled Trials databases, as well as the reference lists of the retrieved studies, were used to find trials relevant for assessing the use of TENS to treat OAB.Results: Of the 246 records identified, 8 publications were analyzed in our study. Our analysis found that TENS resulted in a greater decrease of wet days/wk, daily voiding frequency, daily incontinence episodes, and daily number of voids than was observed in the control group. Furthermore, TENS-treated patients showed similar visual analogue scale (VAS) scores to patients in the control group, demonstrating that the application of TENS did not increase patients’ discomfort and pain. TENS had a relative advantage in the number of partial responses, but no clear differences were found in frequency of no response or a full response compared to the control group. In urodynamic testing, TENS led to obvious improvements in average voided volume and maximum voided volume in children with OAB.Conclusions: TENS had a remarkable effect on the improvement of urodynamic indexes and objective OAB symptoms without a significant increase in VAS scores for children with OAB.
This meta-analysis was performed to evaluate the efficacy and safety of tadalafil
plus tamsulosin compared with tadalafil alone in treating men with benign
prostatic hyperplasia (BPH) and erectile dysfunction (ED) after 12 weeks’
treatment. Systematic review was carried out using the Preferred Reporting Items
for Systematic Reviews and Meta-analyses. MEDLINE, EMBASE, and the Cochrane
Controlled Trials Register were searched to collect randomized controlled
trials. The references of related articles were also searched. Four articles
including 621 patients were involved in the analysis. The study identified that
combination-therapy had significant improvements in total international prostate
symptom score (IPSS), quality of life (QoL) and maximum urine flow rate (Qmax)
compared with monotherapy, and there were no obvious significance in respects of
post-void residual volume, international index of erectile function and IPSS
storage. The difference of total IPSS was mainly reflected in the change of IPSS
voiding. For safety, combination-therapy had a higher incidence rate of any
adverse events (AEs) and discontinuation due to AEs than monotherapy with the
exception of pain. In conclusion, the combination of tadalafil and tamsulosin
provided a better improvement of IPSS voiding, QoL and Qmax compared with
tadalafil alone in treating men with BPH and ED, and the former therapy appeared
to show a higher incidence of AEs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.