A novel dehydrogenative coupling
reaction of N-fluorocarboxamides with polyfluoroarenes
forming C(sp2)–C(sp3) bonds enabled by
copper catalysis has
been accomplished. N-Fluorocarboxamides are postulated
to undergo copper-mediated dehydrogenative cross-coupling reaction
with electron-deficient polyfluoroarenes via a radical pathway. Benzylic
C–H bonds and aliphatic C–H bonds in N-fluorocarboxamides could proceed smoothly and demonstrated excellent
regioselectivity. The detailed mechanism presented is supported by
control experiments and density functional theory calculations.
C-Aryl glycosides are of high value as drug candidates. Here a novel and cost-effective nickel catalyzed ortho-CAr-H glycosylation reaction with high regioselectivity and excellent α-selectivity is described. This method shows...
A metal-free brand-new one-pot multinitrogenation of amides for the chemo- and regioselective synthesis of 1,5-disubstituted tetrazoles has been developed. By means of electrophilic amide activation, and further C-C bond cleavage and rearrangement, a diverse set of functionalized 1,5-DST derivatives were selectively constructed under mild conditions. As showcased in the mechanisms, the chemoselectivity is easily switched by the selection of the starting materials in the reaction.
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