Abstract:Three new sesquilignans, 1-3, a new sesquiterpenoid, 4, and three known compounds were isolated from the stem barks of Illicium simonsii. The structures of new compounds (1-4) were elucidated by spectroscopic methods. A biosynthetic pathway was proposed for simonsienols A-C (1-3). Anti-AChE activity and anti-BuChE activity were evaluated for all compounds except for α-cadinol ethyl ether (4). As a result, isodunnianol (7) exhibited anti-AChE activity with an IC 50 value of 13.0 µM.
Chemical investigation of the aerial parts of Illicium simonsii resulted in the isolation of nine new compounds, simonsols A-E (1-5), simonsins A-B (7-8), terpene-sesquineolignans, clovanedunnianol (9), and p-menthadunnianol (10). Compound 5 was equilibrated with 7 as an inseparable mixture. The structures were elucidated by extensive NMR and MS analysis. Compounds 9, 10, and the mixture of 5 and 7 moderately inhibited acetylcholinesterase with IC50 values of 4.58 µM, 6.55 µM, and 10.34 µM, respectively.
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