All together: A concise strategy for the first diastereoselective total synthesis of (±)‐schindilactone A is reported. The synthesis features a ring‐closing metathesis, a thiourea/cobalt‐catalyzed Pauson–Khand reaction, and a thiourea/palladium‐catalyzed carbonylative annulation reaction. The chemistry can be applied to the synthesis of structures related to schindilactone A.
The total synthesis of (±)-decinine has been achieved. The key steps in the synthesis involved the formation of lasubine II via a gold catalyzed annulation of 1-(but-3-yn-1-yl)piperidine and the formation of the 12-membered ring of decinine (1) with complementary atropselectivity via a VOF3-mediated oxidative biaryl coupling reaction.
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