Background
Considering the strong attenuation of photons and the potential to increase the deposition of radiation, high-atomic number nanomaterials are often used as radiosensitizers in cancer radiotherapy, of which gold nanoparticles (GNPs) are widely used.
Materials and Methods
We prepared albumin-modified GNPs (Alb-GNPs) and observed their radiosensitizing effects and biotoxicity in human non-small-cell lung carcinoma tumor-bearing mice models.
Results
The prepared nanoparticles (Alb-GNPs) demonstrated excellent colloidal stability and biocompatibility at the mean size of 205.06 ± 1.03 nm. Furthermore, clone formation experiments revealed that Alb-GNPs exerted excellent radiosensitization, with a sensitization enhancement ratio (SER) of 1.432, which is higher than X-ray alone. Our in vitro and in vivo data suggested that Alb-GNPs enabled favorable accumulation in tumors, and the combination of Alb-GNPs and radiotherapy exhibited a relatively greater radiosensitizing effect and anti-tumor activity. In addition, no toxicity or abnormal irritating response resulted from the application of Alb-GNPs.
Conclusion
Alb-GNPs can be used as an effective radiosensitizer to improve the efficacy of radiotherapy with minimal damage to healthy tissues.
The application demand for UAV in logistics distribution is vast and its accurate and rapid path planning research has practical value. Nowadays, the RRT algorithm is one of the most popular path planning methods for UAV delivery. Although the search of RRT is fast, the planned path is generally not the optimal path. The improved RRT* algorithm improves the way, but the convergence time is long. In this paper, we proposed an improved 3d path planning method based on RRT* based on APF. We introduced gravitation and repulsion in the APF algorithm based on the RRT* algorithm in this paper, and then we added the random point generated sphere to carry out random sampling of local space. Finally, we used MATLAB to compare the simulation results of the three algorithms and verify that the improved 3d path planning algorithm is improved in the aspects of path optimization and operation time.
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