Контактная информация:Вишнёва Елена Александровна, кандидат медицинских наук, заместитель директора НИИ педиатрии по научной работе, заведующая отделом стандартизации и клинической фармакологии, врач аллерголог-иммунолог отделения восстановительного лечения детей с аллергическими болезнями и заболеваниями органов дыхания НИИ педиатрии ННПЦЗД Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) Ротавирусная инфекция (РВИ) -антропонозное высококонтагиозное острое инфекционное заболева-ние, характеризующееся преимущественным поражени-ем желудочно-кишечного тракта в виде гастроэнтерита с симптомами диареи и рвоты, развитием общей инток-сикации, дегидратации и нередко наличием респира-торного (катарального) синдрома в начальном периоде болезни. Вирион ротавируса имеет диаметр 65-75 нм и состоит из электронно-плотного центра (сердцевины) и двух белковых оболочек -внутреннего и наружного капсида [1]. Сердцевина содержит внутренние белки и фрагментированную цепь рибонуклеиновой кислоты (РНК), состоящую из 11 сегментов, которые кодируют продукцию белков -6 структурных (Viral Proteins, VP1-VP7: VP1, VP2, VP3, VP4, VP6, VP7) и 5 неструктур-ных (NSP1-NSP5). Основным компонентом внутреннего капсида является структурный белок VP6 (основная группоспецифическая антигенная детерминанта рота-вируса). В зависимости от его строения ротавирусы подразделяют на 7 серологических групп -A, B, C, D, E, F, G. Наружный капсид вириона образован двумя струк-турными белками, к которым в организме человека ХАРАКТЕРИСТИКА ВОЗБУДИТЕЛЯ
ObjectivesVertical transmission of hepatitis C virus (HCV) is rare compared with other chronic viral infections, despite that newborns have an immature, and possibly more susceptible, immune system. It further remains unclear to what extent prenatal and perinatal exposure to HCV affects immune system development in neonates.DesignTo address this, we studied B cells, innate immune cells and soluble factors in a cohort of 62 children that were either unexposed, exposed uninfected or infected with HCV. Forty of these infants were followed longitudinally from birth up until 18 months of age.ResultsAs expected, evidence for B cell maturation was observed with increased age in children, whereas few age-related changes were noticed among innate immune cells. HCV-infected children had a high frequency of HCV-specific IgG-secreting B cells. Such a response was also detected in some exposed but uninfected children but not in uninfected controls. Consistent with this, both HCV-exposed uninfected and HCV-infected infants had evidence of early B cell immune maturation with an increased proportion of IgA-positive plasma cells and upregulated CD40 expression. In contrast, actual HCV viraemia, but not mere exposure, led to alterations within myeloid immune cell populations, natural killer (NK) cells and a distinct soluble factor profile with increased levels of inflammatory cytokines and chemokines.ConclusionOur data reveal that exposure to, and infection with, HCV causes disparate effects on adaptive B cells and innate immune cell such as myeloid cells and NK cells in infants.
Regardless of viral genotype we found no association between IL28B genotype and the risk of HCV-VT. The IL28B genotype CC, which has been shown to be favourable in other settings, was not protective of HCV-VT. Thus, other factors possibly associated with the risk of HCV-VT need to be explored.
This article presents the results of a study of the nutritional status of children with acute intestinal infections (AII) occurring with hemocolitis syndrome. It was found that the nutritional status reflects the severity of the pathological process, and its dynamics allows to evaluate the effectiveness of therapy. The aim of the work was to study the changes in anthropometric indicators of nutritional status in the treatment of AII with hemocolitis syndrome in children. 50 patients with AII with hemocolitis syndrome aged from 5 months to 8 years were observed in an infectious hospital. Patients were divided by age: group 1 – breast age (n = 10), group 2 – early age (n = 27), group 3 – preschool age (n = 10), group 4 – school age (n = 3). The nutritional status of patients was studied in dynamics on the 1st and 7th day of inpatient treatment according. Analysis of research data was performed using Studentʼs t-test, U-Mann-Whitney test, Kruskal-Wallis criterion. The level and harmony of physical development of children in all groups at the time of admission to the hospital did not differ significantly. In the course of treatment, positive dynamics was noted in group 1 by the values of body mass index (BMI) (p = 0.05), Z-score BMI (p = 0.04), body weight deviation by height (in %) (p = 0.05); in group 2 – by the values of body weight by height (p = 0.05). Positive dynamics of nutrition indicators in group 1 was combined with a high frequency of diagnosis of unspecified forms of AII (60%). The negative dynamics of most indicators was observed in group 3, which was accompanied by a high frequency of diagnosis of refined (bacterial) etiological forms of AII (90%). The obtained data show that the dynamics of nutritional status of patients with AII with hemocolitis syndrome during therapy was more favorable in infants and young children and less favorable in preschool children, depended on the etiology of the disease and reflected its impact on metabolism.
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