Introduction: Osimertinib is a third-generation EGFRtyrosine kinase inhibitor (TKI). Durvalumab is an antiprogrammed death ligand 1 monoclonal antibody. The phase III open-label CAURAL trial (NCT02454933) investigated osimertinib plus durvalumab versus osimertinib monotherapy in patients with EGFR-TKI sensitizing and EGFR T790M mutation-positive advanced NSCLC and disease progression after EGFR-TKI therapy.
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