Synthesis of labelled epibrassinolide containing two deuterium atoms in a position which is not subjected to isotopic exchange is reported. Key transformations include preparation of 6,7-seco steroidal diacid, its cyclization to a cyclic anhydride followed by a regioselective reduction with NaBD 4 . The obtained [7, H 2 ]epibrassinolide can be used in biochemical experiments when the loss of isotopic label should be avoided.
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