This feature article summarized the recent progress on the construction of metallacycle/metallacage-cored supramolecular polymers by the hierarchical self-assembly, and the potential applications in the areas of light emitting, sensing, bio-imaging, delivery and release, etc., are also presented.
Triple-negative breast cancer (TNBC) is a special subtype of breast cancer, accounting for 10-20% of breast cancers with high intrinsic heterogeneity. Its unique immune microenvironment, including high expression of vascular endothelial growth factors, tumor infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and other molecules that promote the growth and migration of tumor cells, has been shown to play a dual role in the occurrence, growth, and metastasis of TNBC. Understanding the TNBC microenvironment is of great significance for the prognosis and treatment of TNBC. In this article, we describe the composition and function of immune cells in the TNBC microenvironment and summarize the major cytokine growth factors and chemokines in the TNBC microenvironment. Finally, we discuss the progress of TNBC, cytokine-induced killer cell therapy, and immune checkpoint therapy.
Synergistic therapy with nanocarriers is a promising strategy for effective cancer treatment. Here, we synthesized an amphiphilic rhomboidal metallacycle M, in which a glucose-modified pyridine ligand was used to improve water-solubility and an organoplatinum(II) receptor acted as a platinum-based anticancer agent. Moreover, because of the amphiphilic properties, M self-assembled into micelles or nanobelts at different concentrations, and a drug delivery system (DDS) was developed by encapsulating the anticancer drug doxorubicin (DOX) into the micelles. The morphology, cell uptake, cytotoxicity, internalization, and antitumor effect of the DDS were investigated. Under low intracellular pH conditions, the DDS disassembled to release the loaded DOX in situ. The designed DDS exhibited good biocompatibility, synergistic antitumor efficacy, and negligible adverse effects in a U87 tumor-bearing mice model.
Glioma is the most common malignant tumor of the central nervous system (CNS), with high degree of malignancy and poor prognosis. The gut microbiome (GM) is composed of microorganisms with different properties and functions, which play an important role in human physiology and biological activities. It has been proved that GM can affect the development of glioma through natural immunity, but whether GM can affect glioma through adaptive immunity and whether there are some microorganisms in the GM that may affect glioma growth still remain unclear. In our study, we evaluated the relationship between GM and glioma. We proved that (I) glioma growth can induce structural changes of mouse GM, including the decreased abundance of Bacteroidia and increased abundance of Firmicutes. (II) GM dysbiosis can downregulate Foxp3 expression in the brain and promote glioma growth. A balanced environment of GM can upregulate the expression of Foxp3 in the brain and delay the development of glioma. (III) The increased abundance of Bacteroidia is associated with accelerated glioma progression, while its decreased abundance is associated with delayed glioma progression, which may be one of the key microorganisms affecting glioma growth. This study is helpful to reveal the relationship between GM and glioma development and provide new ideas for adjuvant therapy of glioma.
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