No abstract

Left atrial strain derived by cardiac MRI was associated major adverse cardiac events after ST-segment elevation myocardial infarction, overriding outcome predictors such as left atrial volume and left ventricular function. Key Results STEMI patients with impaired left atrial reservoir strain (21.8% or less) and conduit strain (10.5% or less) had significantly higher long-term risk of major adverse cardiac events than patients with reservoir strain larger than 21.8% and conduit strain larger than 10.5% (Log rank P < .001). Left atrial reservoir (hazard ratio, 0.84; P < .001) and conduit (hazard ratio, 0.81; P < .001) strains were independent predictors of major adverse cardiac events after STEMI, after adjusting for all included clinical and cardiac MRI outcome markers. The models including left atrial reservoir and conduit strains on top of traditional outcome markers had higher prognostic accuracy in predicting major adverse cardiac events than the model with only traditional outcome markers (Uno's C statistic, 0.

No abstract

SpostC-induced cardioprotection against H/R injury was impaired under high glucose concentrations, but the inhibition of excess mitochondrial fission restored these effects.

This study demonstrates for the first time that abolishment of the cardioprotective effects of SpostC in diabetic rats is associated with impairment of the HIF-1 signalling pathway and that DFO can activate HIF-1 to restore these cardioprotective effects of SpostC in diabetic rats.