Background Nonalcoholic fatty liver disease (NAFLD) patients are often prone to coronary artery disease (CAD), and CAD is found to be the main cause of death in NAFLD patients. The purpose of this study was to investigate the association between fatty acid desaturase 2 (FADS2) rs3834458 polymorphism and serum FADS2 level with NAFLD and CAD in Chinese Han population. Materials and Methods The serum level of FADS2 was detected by enzyme-linked immunosorbent assay (ELISA) in healthy people, NAFLD patients, and NAFLD patients combined with CAD (NAFLD+CAD). Polymerase chain reaction (PCR) was used to detect the genotypes of FADS2 rs3834458 in the three groups. Results Body mass index (BMI), glucose (GLU), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) of the NAFLD group and the NAFLD+CAD group were higher than those of the healthy control group (P < 0.05); the HDL-C of the NAFLD+CAD group was significantly lower than that of the healthy people and the NAFLD group (P < 0.05). The serum FADS2 concentration in the NAFLD+CAD group was significantly higher than that in the NAFLD group (P < 0.05) and the healthy people (P < 0.05). There was no significant difference in genotype distribution (χ2 = 5.347, P < 0.497) and allele frequency (χ2 = 3.322, P = 0.345) between the three groups. Logistic regression analysis showed that the T allele was not an independent risk factor for CAD with NAFLD (OR = 1.62, 95% CI: 0.422-6.180). Conclusions Serum FADS2 concentration was positively correlated with the susceptibility of NAFLD with CAD, while the polymorphism of rs3834458 was not associated with NAFLD with CAD.
With the market competition intensifies, enterprises focusing on core business has become the most important rules of survival. Therefore, more and more enterprises adopt outsourcing as criticalbusiness initiatives due to itseffectively reduce costs, enhancing the core competitiveness of enterprises and other characteristics. Duroc, a famous American management scholars had predicted: “In ten to fifteen years within any business background to support not only to do the work of creating turnover should be outsourced.” Do what you do best (your core competency) and outsource the rest.It has become an irreversible trend.In this paper, we will introduce the business value of IT outsourcing, discuss IT outsourcing industry’s strengths and weaknesses, finally we will provide corresponding countermeasures based on the discussion.
Structural analysis based on complex network theory has been considered promising for security issues of power grids. At the same time, modern power distribution networks with more Distributed Generations (DGs) and Energy Storage Systems (ESS) have taken on more challenges in operation and security issues. This paper proposed a dedicated metric named as Power-SupplyAbility for power distribution networks based on net-ability. Special features of DGs, such as relations of capacities, identification of effective supply area, and limitation in continuous power supply, have been considered in definition. Furthermore, a novel opinion is proposed that the extent of improvement for operation and security by adding DGs also depends on the original structure of the distribution networks. This is an inherent ability of the original networks and could be quantitatively analyzed. Through case studies, this method has been proved to be effective in identifying potential structural vulnerabilities of distribution networks; particularly the impact of DGs on security has been studied. Furthermore, it can help in site selection for DGs by providing different priorities of locations compared with results of other works. This can help to complement other methods to construct a more comprehensive methodology by considering aspects of security, economy, and quality.
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