BackgroundSeveral studies have been conducted in recent years to evaluate the risk of type 2 diabetes mellitus (T2DM) and polymorphisms of interleukin (IL)-10. However, the results remain conflicting rather than conclusive. This meta-analysis aimed to summarize the current evidence from case-control studies that evaluated this association.MethodsWe carried out a search in Medline, EMBASE, and the Chinese National Knowledge Infrastructure (CNKI) database for relevant studies. Data were extracted using a standardized form and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of the association.Results10 studies were included in our meta-analysis and systemic review. Our meta-analysis indicated that IL-10 −1082A/G polymorphism was associated with the risk of T2DM (GA vs. AA: OR = 1.21, 95% CI = 1.03–1.14; GA/GG vs. AA: OR = 1.22, 95% CI = 1.05–1.41), whereas there was no association between IL-10 −592C/A (CC/CA vs. AA: OR = 1.07, 95% CI = 0.59–1.93) or -819C/T (CC/CT vs. TT: OR = 0.93, 95% CI = 0.49–1.75) polymorphism and T2DM risk was found in our study.ConclusionsThis meta-analysis provides strong evidence that IL-10 −1082A/G polymorphism associated with risk of T2DM. However, no association of the IL-10 −592C/A or −819C/T polymorphism with T2DM risk was found. Additional well-designed large studies were required for the validation of our results.

No abstract

ObjectivesThe aim of this study is to investigate the prevalence and determine the possible risk factors of poor sleep quality in Chinese type 2 diabetes patients with insulin treatment.Methods140 type 2 diabetes patients with insulin treatments were enrolled in our study. General characteristics and laboratory testing such glycosylated hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), post-prandial plasma glucose (PPG) were measured. Every patient completed Chinese version of Pittsburgh Sleep Quality Index (PSQI) questionnaire. PSQI global score>5 was defined as poor sleep quality.ResultsGlobal PSQI score was significantly higher in female type 2 diabetes patients with insulin treatment than male (7.52 vs 6.08, P<0.05). After adjusting for age, BMI, FPG, PPG, HbA1c and duration of diabetes, female is still an independent risk factor for poor sleep quality [OR = 2.55, 95% confidence interval (CI) = 1.24–5.27, P = 0.01].ConclusionThe results suggest that we found poor sleep quality in female Chinese type 2 diabetes patients with insulin treatment and these findings may contribute to sleep disorder control in female type 2 diabetes.

A structured SMBG regimen, with training on interpretation of and responses to SMBG readings, increased SMBG frequency and improved HbA1c and the management of insulin-treated T2DM.