The Ubiquitin SystemUbiquitin is a small 76eamino acid protein and is among the most highly conserved proteins ever described. Ubiquitin is Supported by the NIH Early Independence Award DP5-OD019800 (J.H.). Disclosures: J.H. receives royalties from Harvard Medical School related to US patent 9,201,073.The American Society for Investigative Pathology (ASIP) Cotran Early Career Investigator Award recognizes early career investigators with demonstrated excellence as an investigator with recently established or emerging independence and with a research focus leading to an improved understanding of the conceptual basis of disease. John Hanna, recipient of the ASIP 2019 Cotran Early Career Investigator Award, delivered a lecture entitled "Protein Degradation and the Pathologic Basis of Disease" on October 22, 2018, at the Pathobiology for Investigators, Students, and Academicians (PISA) meeting in Ann Arbor, MI.
Phosphorylation of Bfa1 by Kin4 creates a docking site on Bfa1 for the 14-3-3 family protein Bmh1, which in turn weakens Bfa1–centrosome association and promotes symmetric Bfa1 localization to engage the spindle position checkpoint.
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