D uring January 2020, persons in Thailand were tested for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection if they had a combination of fever or respiratory illness and a history of travel to Wuhan, China. Persons determined to be close contacts of a laboratory-confirmed coronavirus disease (COVID-19) case-patient also were tested during enrollment into contact tracing. Clinicians were able to request testing if they had a concern regarding persons who were exposed to travelers. During January 8-31, 2020, Bamrasnaradura Infectious Diseases Institute, the national infectious disease referral hospital in Bangkok, admitted 11 patients with laboratoryconfirmed COVID-19. We describe clinical features, clinical management, and results of serial reverse transcription PCR (RT-PCR) testing for SARS-CoV-2 RNA for these patients.
Median plasma efavirenz levels were comparable among both groups. Efavirenz 600 mg/day should be sufficient for most Thai HIV-infected patients receiving rifampicin with body weight approximately 50 kg. These results may not be applicable to other ethic populations who have higher body weights. However, the study of long-term virological and immunological outcomes is needed and under further investigation.
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